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Equilibrium Constants for the Complexation of Metal Ions by Serum Transferrin

  • Wesley R. Harris
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 249)

Abstract

In mammals iron is transported through blood as ferric ion bound tightly to serum transferrin, which is one member of a small family of iron binding proteins that includes ovotransferrin and lactoferrin (Brock, 1985; Chasteen, 1983; Aisen & Listowsky, 1980). The distinguishing characteristic of the transferrins is the requirement of a synergistic anion to achieve strong metal binding. In the body bicarbonate serves this function. Binding of the anion precedes metal binding (Kojima & Bates, 1981). In the absence of bicarbonate, metal binding is not strong enough to prevent hydrolysis of ferric ion, so that bicarbonate serves as an “all-or-nothing” switch for iron binding.

Keywords

Binding Constant Metal Binding Serum Zinc Serum Transferrin Linear Free Energy Relationship 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Wesley R. Harris

There are no affiliations available

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