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Mechanisms of Intestinal Brush Border Iron Transport

  • Robert J. Simpson
  • Kiskor B. Raja
  • Timothy J. Peters
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 249)

Abstract

Mucosal uptake represents the first cellular step in iron absorption and is the point at which the cell biochemistry of iron absorption and the nutritional chemistry of dietary iron interact. Mucosal uptake was identified as a distinct step in the iron absorption process about 30 years ago (Manis & Schachter, 1962) and several groups of workers have since investigated the kinetics and mechanism of mucosal uptake in experimental animals in vivo and with various in vitro preparations. Different viewpoints regarding mucosal uptake emerged from these studies and key experimental findings were not always in agreement. For example, studies with in vitro incubated tissue failed to agree on whether the initial uptake step is regulable, saturable or regional (Sheehan, 1976; Acheson & Schultz, 1972; Cox & O’Donnell, 1982). In vivo studies also conflict as to whether uptake shows saturation kinetics (Wheby et al., 1964; Thompson & Valberg, 1971; Moore et al., 1964).

Keywords

Divalent Cation Brush Border Brush Border Membrane Brush Border Membrane Vesicle Hypobaric Chamber 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Robert J. Simpson
  • Kiskor B. Raja
  • Timothy J. Peters

There are no affiliations available

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