Mechanisms of Intestinal Brush Border Iron Transport
Mucosal uptake represents the first cellular step in iron absorption and is the point at which the cell biochemistry of iron absorption and the nutritional chemistry of dietary iron interact. Mucosal uptake was identified as a distinct step in the iron absorption process about 30 years ago (Manis & Schachter, 1962) and several groups of workers have since investigated the kinetics and mechanism of mucosal uptake in experimental animals in vivo and with various in vitro preparations. Different viewpoints regarding mucosal uptake emerged from these studies and key experimental findings were not always in agreement. For example, studies with in vitro incubated tissue failed to agree on whether the initial uptake step is regulable, saturable or regional (Sheehan, 1976; Acheson & Schultz, 1972; Cox & O’Donnell, 1982). In vivo studies also conflict as to whether uptake shows saturation kinetics (Wheby et al., 1964; Thompson & Valberg, 1971; Moore et al., 1964).
KeywordsDivalent Cation Brush Border Brush Border Membrane Brush Border Membrane Vesicle Hypobaric Chamber
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