Magnesium Deficiency/Loss from Myocardium

  • Mildred S. Seelig
Part of the Topics in Bone and Mineral Disorders book series (TBMD)


The foregoing section has dealt predominantly with the evidence that magnesium deficiency can be contributory to arterial lesions (culminating either in sudden death or in chronic atherosclerosis) that are implicated in the cardiovascular diseases of civilization. Raab (1972), in his introduction to a symposium on myocardiology, commented that the current “official” approach to the problem of degenerative heart disease represents adherence to “traditional but outdated concepts that imply a purely, or almost purely coronary vascular origin of fatal myocardial lesions.” He referred to evidence that in about half the deaths clinically attributed to “myocardial infarctions,” “coronary occlusions,” “coronary thrombosis,” or “coronary artery disease,” no thrombi or vascular occlusions were found on autopsy (Baroldi, 1969, 1970/1972; Spain and Bradess, 1960). He suggested that the term “coronary heart disease” be replaced by one referring to “cardiac hypoxic dysionism,” as encompassing the ionic myocardial changes produced in association with the myocardial hypoxia resulting from a decreased oxygen supply (coronary insufficiency) in conjunction with stress-induced hormonal (catecholamine) increased oxygen demand (Raab, 1969). As depicted in Fig. 7–1 (Raab, 1972), hypoxia causes decreased myocardial concentrations of both magnesium and potassium and increased myocardial sodium. This dysionic pattern is contributed to by stress-induced corticosteroid secretion.


Magnesium Level Myocardial Necrosis Magnesium Deficiency Myocardial Lesion Cardiomyopathic Hamster 
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Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • Mildred S. Seelig
    • 1
  1. 1.Goldwater Memorial HospitalNew York University Medical CenterNew YorkUSA

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