Therapeutic Use of Magnesium in Cardiovascular Disease

  • Mildred S. Seelig
Part of the Topics in Bone and Mineral Disorders book series (TBMD)


With such strong evidence that magnesium deficiency—or other factors that cause subnormal magnesium levels—can lead to functional and morphologic cardiovascular abnormalities, it is surprising that there has been so little clinical application of these findings. It is to be hoped that the detailed case reports published by Chadda et al. (1973b) and Iseri et al. (1975), in which they described rapid correction by magnesium of arrhythmias that had been refractory to the widely accepted therapeutic modalities, will stimulate others to consider magnesium treatment and evaluation of the magnesium status of patients with cardiac, and especially life-threatening arrhythmias. It must be cautioned that severe hypomagnesemia is not a necessary finding. For example, Chadda et al. (1973b, 1976/1980) found only slightly subnormal serum magnesium levels, but histories of diuretic intake and myocardial infarctions (which cause magnesium loss) in patients with a high incidence of ventricular ectopia. Iseri et al. (1975) reviewed the clinical states and drugs associated with magnesium deficiency and loss, and pointed out that magnesium deficiency can clearly exist without hypomagnesemia. They cited a reference (Loeb et al., 1968) that demonstrated that hypomagnesemia can predispose to arrhythmia (which eventually responded to standard therapy without magnesium repletion).


Magnesium Sulfate Magnesium Deficiency Magnesium Salt Digitalis Toxicity Magnesium Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • Mildred S. Seelig
    • 1
  1. 1.Goldwater Memorial HospitalNew York University Medical CenterNew YorkUSA

Personalised recommendations