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On the Conformation, Coacervation and Function of Polymeric Models of Elastin

  • Dan W. Urry
  • Marianna M. Long
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 79)

Abstract

In a recent review (1) entitled “Conformations of the Repeat Peptides of Elastin in Solution: An Application of Proton and Carbon-13 Magnetic Resonance to the Determination of Polypeptide Secondary Structure”, the secondary structures of the monomers and polymers of the repeat peptides of tropoelastin were described. The repeat peptides, as reported by Foster et al. (2) and Gray et al. (3) but with the permutation given in terms of the conformational unit, are Val1-Pro2-Gly3-Gly4, Val1-Pro2-Gly3-Val4-Gly5, and Ala1-Pro2-Gly3-Val4-Gly5-Val6. Derivatives of these monomers, their permutations, oligomers and high polymers were studied in four different solvents dimethylsulfoxide, methanol, trifluoroethanol and water. More recently each of the three monomers have been studied in chloroform and their possible conformations examined by means of extensive conformational energy calculations (4–6). In each solvent and in the conformational energy calculations, all of the repeat peptides were found to contain the β-turn with Pro2 and Gly3 at the corners as a dominant conformational feature (see Figure 1). This β-turn utilizes a hydrogen bond between the C-O of residue 1 and the N-H of residue 4.

Keywords

Polymeric Model Rubber Elasticity Secondary Structural Feature Elastomeric Property Repeat Peptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Dan W. Urry
    • 1
  • Marianna M. Long
    • 1
  1. 1.Laboratory of Molecular Biophysics and the Cardiovascular Research andTraining CenterUniversity of Alabama Medical CenterBirmingham, AlabamaUK

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