Ultrastructural Changes of Elastic Tissue in Hamster Lung During Elastase-Emphysema
Recently, the structural arrangement of elastin has been extensively studied by numerous investigators. Subsequently, four molecular models (corpuscular, fibrillar, amorphous random chain, and “oiled coil”) have been proposed (1)(2), based upon evidence of electron microscopic observations as well as from the physico-chemical measurements of ligament elastin. However, elastic tissue in intact tissues or organs has not been studied in detail. In 1966, Banga (3) suggested a structural arrangement of elastic tissues based on her studies under a polarized light microscope and enzymatic digestions. She proposed that the intact elastic fiber consisted of mainly amorphous elastin and a small amount of glycoproteins. However, under the electron microscope, in addition to the amorphous elastin, microfibrils have been found (4)(5) and were identified as a glycoprotein (6–8). They average 130 Å in width and appear tubular. The microfibrils are concentrated on the peripheral portion of elastic fibers and mantled around the amorphous portion of the elastic fibers.
KeywordsUrea Carbohydrate EDTA Citrate Epoxy
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- 1.Sandberg, L.B. 1976. In: International Review of Connective Tissue Research, 7, ed. by D.A. Hall and D. S. Jackson, Academic Press, New York, pp 159–210.Google Scholar
- 2.Gosline, J.M. 1976. In: International Review of Connective Tissue Research, 7, ed. by D.A. Hall and D.S. Jackson, Academic Press, New York, pp. 211–249.Google Scholar
- 3.Banga, I. 1966. Structure and Function of Elastin and Collagen. Akademiai Kiado, Budapest.Google Scholar
- 7.Barnes, M.J. and Partridge, S.M. 1968. Biochem. Biophys. Acta, 40, pp. 367–368.Google Scholar
- 9.Ross, R. and Bornstein, P. 1970. In: Chemistry and Molecular Biology of the Intercel1ular Matrix, ed. by E.A. Balaza, Adademic Press, New York, pp. 641–655.Google Scholar
- 12.Yu, S.Y. and Blumenthal, H.T. (Unpublished data).Google Scholar
- 18.Orsos, F. 1907. Beitr. path. Anat. 41, pp. 95–121.Google Scholar
- 19.Yu, S.Y., Keller, R.N. and Yoshida, A. 1976. In this volume, Biosynthesis of Insoluble Elastin in Hamster Lungs during Elastase-Emphysema.Google Scholar