Studies of the Biosynthesis of a Soluble Precursor of Elastin

  • Don W. Smith
  • Pathrapamkel A. Abraham
  • William H. Carnes
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 79)


A salt soluble protein, isolated from the aortas of copper-deficient swine, has been characterized as a precursor of elastin by its amino acid composition and its incorporation into insoluble aortic elastin in vitro.


Amino Acid Composition Copper Deficiency Sedimentation Equilibrium Normal Aorta Isoleucine Leucine 
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  1. 1.
    Carnes, W.H. (1968) Copper and connective tissue metabolism. International Review of Connective Tissue Research 4, 197–232.PubMedGoogle Scholar
  2. 2.
    Smith, D.W., Weissman, N. and Carnes, W.H. (1968) Cardiovascular studies on copper-deficient swine. XII. Partial purification of a soluble protein resembling elastin, Biochem. Biophys. Res. Commun. 31, 309–315. 3. PartriPubMedCrossRefGoogle Scholar
  3. 3.
    Partridge, S.M. (1966) Biosynthesis and nature of elastin structures, Federation Proc. 25, 1023–1029.Google Scholar
  4. 4.
    Smith, D.W., Brown, D.M. and Carnes, W.H. (1972) Preparation and properties of salt-soluble elastin, J. Biol. Chem. 247, 2427–2432.Google Scholar
  5. 5.
    Smith, D.W. and Carnes, W.H. (1973) Biosynthesis of soluble elastin by pig aortic tissue in vitro, J. Biol. Chem. 248, 8157–8161.Google Scholar
  6. 6.
    Smith, D.W, Abraham, P.A. and Carnes, W.H. (1975) Crosslinkage of salt-soluble elastin in vitro, Biochem. Biophys. Res. Commun. 66, 893–899.Google Scholar
  7. 7.
    Smith, D.W., Abraham, P.A. and Carnes, W.H. Kinetics of elastin synthesis in copper deficiency, Biochem. Biophys. Acta (Submitted).Google Scholar
  8. 8.
    Gallop, P., Blumenfeld, O.O. and Deifter, S. (1972) Structure and metabolism of connective tissue proteins, Ann. Rev. Biochem. 41, 617–672.Google Scholar
  9. 9.
    Murphy, L., Harsch, M., Mori, T. and Rosenbloom, J. (1972) Identification of a soluble intermediate during synthesis of elastin by embryonic chick aortae, FEBS Lett. 21, 113–117.PubMedCrossRefGoogle Scholar
  10. 10.
    Franzblau, C., Faris, B., Lent, R.W., Salcedo, L.L., Smith, B., Jaffe, R. and Crombie, G. (1970) Chemistry and biosynthesis of crosslinks in elastin, In Chemistry and Molecular Biology of the Intercellular Matrix (E. A. Balazs, Ed.), Academic Press, New York, 617–639.Google Scholar
  11. 11.
    Francis, G., Rhys, J. and Thomas, J. (1973) Biosynthetic pathway of desmosines in elastin, Biochem. J. 136, 45–55.Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Don W. Smith
    • 1
  • Pathrapamkel A. Abraham
    • 1
  • William H. Carnes
    • 1
  1. 1.Department of PathologyUniversity of CaliforniaLos AngelesUSA

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