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Crosslinking Profiles of Elastin from Anatomically Defined Regions of the Lung

  • Mercedes A. Paz
  • David A. Keith
  • Paul M. Gallop
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 79)

Abstract

Elastin was isolated and purified by a procedure which sequentially removed lipids, collagen, structural glycoproteins and the microfibrillar proteins. Cross-linking profiles were obtained by column chromatography either after reduction with 3[H]NaBH4 or after reaction with 14[C]NaCN and NH3. Examination of the crosslinking profiles of the elastins from various tissue regions revealed differences in the type, distribution and quality of crosslinks.

Keywords

Alkali Treatment Structural Glycoprotein Aorta Elastin Calf Lung Unreduced Sample 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Paz, M.A., Keith, D.A., Traverse H.P. and Gallop, P.M., Biochemistry (in press).Google Scholar
  2. 2.
    Richmond, V. (1974) Biochim. Biophys. Acta 351, 173.PubMedCrossRefGoogle Scholar
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    Paz, M.A., Gallop, P.M., Blumenfeld, O.O., Henson, E. and Seifter, S. (1971) Biochem. Biophys. Res. Commun. 43, 289.PubMedCrossRefGoogle Scholar
  4. 4.
    Pereyra, B., Paz, M.A., Gallop, P.M. and Blumenfeld, O.O. (1973) Biochem. Biophys. Res. Commun. 55, 96.PubMedCrossRefGoogle Scholar
  5. 5.
    Pereyra, B., Blumenfeld, O.O., Paz, M.A., Henson, E. and Gallop, P.M. (1974) J. Biol. Chem. 249, 2212.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Mercedes A. Paz
    • 1
  • David A. Keith
    • 1
  • Paul M. Gallop
    • 1
  1. 1.Departments of Biological Chemistry, Orthopaedic Surgery and Oral BiologyHarvard Medical School, Harvard School of Dental Medicine, and Children’s Hospital Medical CenterBostonUSA

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