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Evolution of Elastin Structure

  • E. H. Sage
  • W. R. Gray
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 79)

Abstract

The aortae of a number of vertebrates and invertebrates were tested for the presence of elastin to determine when this protein first appears phylogenetically. Using several criteria, including amino acid composition, presence of desmosines, and histological characteristics, we found that all representative vertebrate groups have elastin except the primitive jawless fishes (lampreys and hagfishes). All the invertebrates tested, representing most major phyla, were found lacking in elastin as well. Comparison of purified elastins from several vertebrate groups reveals some striking differences in their amino acid compositions and properties, including the arrangement of the elastic fibers in the aorta. The patterns of variations in amino acid composition suggest a mode of evolution which is different from the slow accumulation of point mutations observed with globular proteins.

Keywords

Amino Acid Composition Amino Acid Analysis Cyanogen Bromide Elastin Content Invertebrate Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • E. H. Sage
    • 1
  • W. R. Gray
    • 1
  1. 1.Department of BiologyUniversity of UtahSalt Lake CityUSA

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