The Morphogenesis of Elastic Fibers

  • Russell Ross
  • Philip J. Fialkow
  • Lawrence K. Altman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 79)


Elastic fibers have been shown to contain two proteins, insoluble elastin and the elastic fiber microfibril, a glycoprotein. The microfibril has been suggested to play a morphogenetic role in determining the presumptive shape and direction of the forming elastic fiber. The principal alteration seen in individuals with the disease Pseudoxanthoma Elasticum is in insoluble elastin which loses its amorphous appearance and affinity for anionic stains, and takes on a finely granular appearance and shows increased affinity for cationic stains. Normal elastic fiber microfibrils are sometimes associated with this material; although, in general, these structures are not present in the elastic fibers that are markedly altered in this disease.


Elastic Fiber Polar Amino Acid Granular Appearance Pseudoxanthoma Elasticum Digital Flexor Tendon 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Russell Ross
    • 1
  • Philip J. Fialkow
    • 1
  • Lawrence K. Altman
    • 1
  1. 1.Department of PathologyUniversity of Washington School of MedicineSeattleUSA

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