Elastase-Like Enzymes in Aortas and Human Breast Carcinomas: Quantitative Variations with Age and Pathology

  • W. Hornebeck
  • L. Robert
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 79)


Two neutral proteases have been isolated from aortas and human breast tumors. The aortic elastase-1ike enzyme has been further purified. The details of this purification procedure will be given and some of the properties of the purified enzyme (susceptibility to various kinds of substrates, degree of Inhibition of serum inhibitors, α1-antitrypsin and α2-macroglobulin). This elastinolytic activity of the aorta increased with age and with the degree of atherosclerosis. Both parameters seem to act independently and in a cumulative fashion.

Elastinolytic activity has been demonstrated in extracts of human breast carcinomas and is exponentially related to the age of the patient. There exists a parallel neosynthesis of elastin which increased also with the age of the patient. Some characteristics of the polymeric elastin isolated from the tumor tissue will be given.

The possible role of this neutral protease present in human aortas and human breast carcinomas will be discussed.


Breast Carcinoma Elastic Fiber DEAE Cellulose Human Breast Carcinoma Neutral Protease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • W. Hornebeck
    • 1
  • L. Robert
    • 1
  1. 1.Lab. Biochimie du Tissu Conjonctif Fac. MédecineUniv. Paris-Val de MarneCreteilFrance

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