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Organization of Glycoprotein and Glycolipid in the Plasma Membrane of Normal and Transformed Cells as Revealed by Galactose Oxidase

  • Chapter
Biomembranes

Part of the book series: Biomembranes ((B,volume 8))

Abstract

Plasma membranes of mammalian cells have been characterized by their higher content of glycosphingolipids (Weinstein et al., 1967; Dod and Gray, 1968; Klenk and Choppin, 1970; Renkonen et al., 1970; Yogeeswaran et al., 1972; Critchley et al., 1973) and by the presence of a particular glycoprotein, as indicated by the higher incorporation of radioactive fucose or glucosamine into isolated plasma membranes (Gahmberg, 1971). In fact, the amounts of glycolipids and of protein-bound fucose are good markers for plasma membranes (Renkonen et al., 1970; Gahmberg, 1971). During the last several years, surface carbohydrates have been implicated in a variety of biological phenomena, such as cellular adhesion (Roseman, 1971; Roth and White, 1972), the lymphocyte homing phenomenon (Gesner and Ginsburg, 1964), lectin-induced agglutination of transformed cells (Burger, 1969; Inbar and Sachs, 1969), specific recognition of homologous cells by tectal cells during a particular term of development (Gottlieb et al., 1974), and histotypic aggregation of retinal cells (Lilien and Moscona, 1967; Moscona, 1971) and of sponge cells (Humphrey, 1963).

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Author information

Author notes

  1. Carl G. Gahmberg

    Present address: Department of Serology and Bacteriology, University of Helsinki, Helsinki, Finland

Authors and Affiliations

  1. Departments of Pathobiology and Microbiology, University of Washington, Seattle, Washington, USA

    Carl G. Gahmberg

  2. The Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

    Sen-itiroh Hakomori

Authors
  1. Carl G. Gahmberg
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  2. Sen-itiroh Hakomori
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Editors and Affiliations

  1. The Wistar Institute, Philadelphia, Pennsylvania, USA

    Lionel A. Manson

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© 1976 Plenum Press, New York

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Gahmberg, C.G., Hakomori, Si. (1976). Organization of Glycoprotein and Glycolipid in the Plasma Membrane of Normal and Transformed Cells as Revealed by Galactose Oxidase. In: Manson, L.A. (eds) Biomembranes. Biomembranes, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9087-9_4

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  • DOI: https://doi.org/10.1007/978-1-4684-9087-9_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-9089-3

  • Online ISBN: 978-1-4684-9087-9

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