Distribution of Transplantation Antigens on Cell Surfaces

  • William C. Davis
  • Howard E. Sandberg
  • Paul H. DeFoor
Part of the Biomembranes book series (B, volume 8)


Rapid advances have been made in elucidating the genetics and biochemistry of cell surface components which behave as the major transplantation antigens in mice (H-2) (Klein and Shreffler, 1971) and man (HL-A) (Amos, 1969; Walford, 1969). In both, the antigens are highly polymorphic and are determined by a complex region of chromosome subdivisible by crossover into at least two subregions, each of which codes for a series of serologically defined antigenic specificities. In the mouse, the H-2D and H-2K regions are separated by two gene loci, the Ss-Slp and the Ir (Klein and Shreffler, 1971, 1972; Snell, 1971). In man, no conclusive evidence has been obtained on whether the two subregions of the HL-A system, the first and second segregant series, are separated by other gene loci.


Electron Paramagnetic Resonance Electron Paramagnetic Resonance Spectrum Erythrocyte Membrane Cell Surface Antigen Antigenic Site 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • William C. Davis
    • 1
  • Howard E. Sandberg
    • 2
  • Paul H. DeFoor
    • 1
  1. 1.Departments of Veterinary Microbiology and Pathology College of Veterinary MedicineWashington State UniversityPullmanUSA
  2. 2.Biophysics Program College of Sciences and ArtsWashington State UniversityPullmanUSA

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