In Vivo and In Vitro Interactions of Chlorpromazine and Melanin
A pronounced affinity between melanin and chlorpromazine has been known since the early 1960’s, when Potts  in this country and Rutschmann and associates  of the Sandoz Laboratories at Basel detected accumulation of phenothiazine derivatives in the melanin-bearing eye tissues of experimental animals. The drug concentration was found to exceed the uniform rate of distribution by a factor of 30 to 50, depending on the phenothiazine compound used. We previously reported on chlorpromazine levels in the autopsied tissues of a chronically dosed patient  and found the drug content in hair higher than in any of the visceral, bone, or keratinous tissues examined. In 1964, Greiner and his group [4–6] called attention to late side effects of high and prolonged doses of chlorpromazine, manifested by “melanosis” in a genetically predisposed group of patients.
KeywordsDrug Content Glucuronic Acid Dose Patient Drug Metabolite Phenothiazine Derivative
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