Dynamic Aspects of Chlorpromazine Metabolism

  • F. W. Grant


The critical importance of O-and N-methylationinneurobiochemistry and pharmacology is apparent in current interest in such compounds as DMPEA, mescaline, reserpine, bufotenin, and epinephrine, to mention but a few. The ubiquitous N-methyl functional group is also common to a wide variety of psychotherapeutic agents, such as chlorpromazine, chlordiazepoxide, imipramine, amitriptyline, etc. Our work is predicated on the idea that certain metabolic pathways may be shared by these substances and that behavioral anomalies may be reflected in changing patterns of metabolic methylation and demethylation.


Dynamic Aspect Methylation Index Tertiary Amine Group Behavioral Anomaly Optimum Therapeutic Dosage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 1968

Authors and Affiliations

  • F. W. Grant

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