Symposium: The Biology of Learning and Memory
Recent studies with a new automated apparatus confirm our earlier reports that puromycin and acetoxycycloheximide, two inhibitors of protein synthesis, each block memory formation in the goldfish, but do not block learning. All of our studies taken together suggest that there are at least two stages of memory formation. We have demonstrated that acetoxycycloheximide is over 1000 times more potent in both its memory-blocking and protein-synthesis-inhibiting properties than puromycin. The period of time following training in which injection of these agents is effective is only a few hours, but the decay of short-term memory associated with learning takes days. We have also shown that exteroceptive stimuli affect the onset of the memory-forming process.
KeywordsSalient Function Past President Amnestic Effect Exteroceptive Stimulus Research Career Development Award
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