Maturational Changes in Amino Acids in CNS of Different Mammalian Species

  • Harish C. Agrawal
  • Jimmie M. Davis
  • Williamina A. Himwich


The central nervous system (CNS) of rodents, cats, and dogs undergoes profound biochemical and functional alterations during postnatal ontogenesis under normal environmental conditions. The biochemical, physiological, and functional integration of the brain is accompanied by morphological differentiation and by electrophysiological maturation during the postnatal period in most of the rodents (with the exception of the guinea pig) in which rapid development of the CNS occurs during prenatal life [12]. The study of amino-acid metabolism in the developing brain deserves special consideration because of its great significance in the mechanisms of cellular growth and myelination and in the synthesis of proteins, nucleic acids, biogenic amines, lipids, and phospholipids. In recent years, the study of free amino acids and related enzymes in the developing brain of different mammalian species has attracted increasing interest, not only in biochemistry and neurochemistry, but also in such fields as pharmacology, psychopharmacology, physiology, and genetics. Our interest in the comparative amino-acid metabolism of the developing brain has led us to collect data for different species.


Glutamic Acid Aspartic Acid Free Amino Acid Glutamic Acid Decarboxylase Postnatal Development 
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  1. 1.
    Agrawal, H.C., Davis, J.M., and Himwich, W. A.: Postnatal changes in free amino acid pool of rat brain, J. Neurochem. 13:607, 1966.PubMedCrossRefGoogle Scholar
  2. 2.
    Agrawal, H.C., Davis, J.M., and Himwich, W. A.: Postnatal changes in free amino acid pool of rabbit brain. Brain Res. 3:374, 1966/1967.PubMedCrossRefGoogle Scholar
  3. 3.
    Baxter, C.F., Schade’, J.P., and Roberts, E.: Maturational changes in cerebral cortex. II. Levels of glutamic acid decarboxylase, y -aminobutyric acid and some related amino acids, in: Roberts, E. (ed.). Inhibition in the Nervous System and Gamma Aminobutyric Acid, Pergamon Press, London, 1960, p. 214.Google Scholar
  4. 4.
    Berl, S., and Purpura, D. P.: Postnatal changes in amino acid content of kitten cerebral cortex, J. Neurochem. 10:237, 1963.PubMedCrossRefGoogle Scholar
  5. 5.
    Berl, S., and Purpura, D.P.: Regional development of glutamic acid compartmentation in immature brain, J. Neurochem. 13:293, 1966.CrossRefGoogle Scholar
  6. 6.
    Coxon, R. V., and Peters, R. A.: The effect of oxygen and of cocarboxylase on the formation of citrate and a-ketoglutarate by pigeon brain homogenates, Biochem. J. 46:300, 1950.PubMedGoogle Scholar
  7. 7.
    Davison, A.N.: Amino acid decarboxylases in rat brain and liver, Biochim. Biophys. Acta 19:66, 1956.CrossRefGoogle Scholar
  8. 8.
    Dravid A.R., Himwich, W.A.: Biochemical studies of the central nervous system of the dog brain during maturation, in: Himwich, W. A., and Himwich, H.E. (eds.). Progress in Brain Research, Vol. 9, The Developing Brain, Elsevier, Amsterdam, 1964, p. 170.Google Scholar
  9. 9.
    Dravid, A. R., Himwich, W. A., and Davis, J.M.: Some free amino acids in dog brain during development, J. Neurochem. 12:901, 1965.PubMedCrossRefGoogle Scholar
  10. 10.
    Flexner, L.B.: Enzymatic and functional pattern of the developing mammalian brain, in: Waelsch, H. (ed.). Biochemistry of the Developing Nervous System, Academic Press, New York, 1955, p. 281.Google Scholar
  11. 11.
    Flexner, L.B., Flexner, J.B., Roberts, R.B., and de la Haba, G.: Lactic dehydrogenase of the developing cerebral cortex and liver of the mouse and guinea pig. Developmental Biology 2:313, 1960.PubMedCrossRefGoogle Scholar
  12. 12.
    Flexner, L.B., Tyler, D.B., and Gallant, L.J.: Biochemical and physiological differentiation during morphogenesis. X. Onset of electrical activity in developing cortex of the foetal guinea-pig, J. Neurophysiol. 13:427, 1950.PubMedGoogle Scholar
  13. 13.
    Himwich, W. A., Davis, J.M., and Agrawal, H.C.: Biochemical substrata for the development of the mature evoked potential, in: Wortis, J. (ed.), Biological Psychiatry, Vol. 9, Plenum Press, New York, 1967. p. 271.Google Scholar
  14. 14.
    Himwich, W.A.: Biochemical and neurophysiological development of the brain in the neonatal period, Intern. Rev. Neurobiol. 4:117, 1962.CrossRefGoogle Scholar
  15. 15.
    Karki, N., Kuntzman, R., and Brodie, B.B.: Storage, synthesis, and metabolism of monoamines in the developing brain, J. Neurochem. 9:53, 1962.PubMedCrossRefGoogle Scholar
  16. 16.
    Oja, S. S., and Pina, R. S.: Changes in the concentration of free amino acids in the rat brain during postnatal development. Life Sci. 5:865, 1966.PubMedCrossRefGoogle Scholar
  17. 17.
    Ramirez De Guglielmone, Alicia E., and Gomez, D. J.: Influence of neonatal hypothyroidism on amino acids in developing rat brain, J. Neurochem. 13:1017, 1966.CrossRefGoogle Scholar
  18. 18.
    Roberts, E., Harman, J. P., and Frankel, S.: Gamma-aminobutyric acid content and glutamic acid decarboxylase activity in developing mouse brain, Proc. Soc. Exptl. Biol. (New York) 78:799, 1951.Google Scholar
  19. 19.
    Schade, J.P., and Pascoe, E.G.: Maturational changes in cerebral cortex. III. Effects of methionine sulfoximine on some electrical parameters and dendritic organisation of cortical neurons, in: Himwich, W.A., and Himwich, H.E. (eds.). Progress in Brain Research, Vol. 9, The Developing Brain, Elsevier, Amsterdam, 1964, p. 132.Google Scholar
  20. 20.
    Spackman, D.H., Stein, W.H., and Moore, S.: Automatic recording apparatus for use in the chromatography of amino acids. Anal. Chem. 30:1190, 1958.CrossRefGoogle Scholar
  21. 21.
    Tews, J.K., and Stone, W.A.: Free amino acids and related compounds in brain and other tissues: Effects of convulsant drugs, in: Himwich, W.A., and Schadé, J.P. (eds.), Progress in Brain Research, Vol. 16, Horizons in Neuropsychopharmacology, Elsevier, Amsterdam, 1965, p. 135.Google Scholar
  22. 22.
    Tissari, A.: 5-Hydroxytryptamine, 5-hydroxytryptophan decarboxylase and monoamine oxidase during foetal and postnatal development in the guinea pig. Acta Physiol. Scand. 67:1, 1966.CrossRefGoogle Scholar
  23. 23.
    Vernadakis, A., and Woodbury, D.M.: Electrolyte and amino acid changes in rat brain during maturation, Am. J. Physiol. 203:748, 1962.PubMedGoogle Scholar
  24. 24.
    van den Berg, C. J., van Kempen, G. M. J., Schadé, J. P., and Veldstra, H.: Levels and intracellular localization of glutamate decarboxylase and γ-aminobutyrate transaminase and other enzymes during the development of the brain, J. Neurochem. 12:863, 1965.PubMedCrossRefGoogle Scholar
  25. 25.
    Waelsch, H.: Glutamic acid and cerebral function, Advan. Protein Chem. 6:299, 1951.CrossRefGoogle Scholar

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© Springer Science+Business Media New York 1968

Authors and Affiliations

  • Harish C. Agrawal
  • Jimmie M. Davis
  • Williamina A. Himwich

There are no affiliations available

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