Psychotogenic N,N-Dimethylated Indole Amines and Behavior in Schizophrenic Patients
The presence of norepinephrine, dopamine, and serotonin in the brain of mammals (including man) has been confirmed repeatedly, and the possible physiological role of these amines in the cerebral functions has been discussed. Many neuropsychotropic drugs used in the treatment of mental patients are known to affect the cerebral level of these primary amines. In contrast, N,N-dimethylated indole amines (in the right column in Fig. 1) have evoked psychotomimetic effects in human beings [1–4] or caused behavioral disturbances in experimental animals , Axelrod [6, 7] has demonstrated by in vitro studies that such N,N-dimethylated indole amines could be formed in mammalian tissues from the naturally occurring primary indole amines, such as tryptamine or serotonin. In this reaction, the tryptamine moiety of such N,N-dimeth-ylated indole amines is originally derived from the essential amino acid, tryptophan (Fig. 1), and the methyl groups can be supplied by a methyl donor such as methionine or betaine.
KeywordsPsychotic Symptom Schizophrenic Patient Indole Amine Trimethylsilyl Ether Mental Symptom
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