Diphenylhydantoin and Procainamide: Normalization of Suboptimal Learning Behavior
In this paper we explore positive drug effects on the learning behavior of two classes of rats characterized by learning deficit—the aged rat and the young adult rat made deficient by a procedure involving the intraperitoneal injection of 10–20% body weight of 5.5% dextrose, originally developed by Darrow and Yannet . This procedure lowers the electroconvulsive-shock threshold, while increasing brain intracellular water and sodium and decreasing total brain electrolytes . Because of their lowered electroconvulsive-shock threshold, rats so treated have been used to evaluate anticonvulsant drugs . That animals so treated also manifest a learning deficit represents a new finding of our laboratory. It will be specifically shown that these animals reflect aspects of the deficit that develops with aging, thereby constituting a limited model for this condition.
KeywordsAged Animal Acquisition Trial Neuronal Hyperexcitability Magnesium Pemoline Shock Frequency
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- 2.Thoman, J.E.P., and Goodman, L.S.: Conditions modifying convulsions in animals, in: Proceedings of Association for Research inNervous and Mental Disease, Vol. 36, 1946, p. 141.Google Scholar
- 3.Welford, A.T.: Performance, biological mechanisms and age: A theoretical sketch, in: Welford, A.T., and Birren, J.E. (eds.), Behavior, Aging, and the Nervous System, Charles Thomas, Springfield, 1965, p. 3.Google Scholar
- 4.Inglis, J.: Immediate memory. Age and Brain Function; in: Welford, A.T., and Birren, J.E. (eds.), Behavior, Aging and the Nervous System, Charles Thomas, Springfield, 1965, p. 88.Google Scholar
- 6.Axelrod, S.: Cognitive tasks in several modalities, in: Williams, R.H., Tibbits, C., and Donahue, W. (eds.), Processes of Aging, Vol. 1, Atherton Press, New York, 1963, p. 132.Google Scholar
- 8.Bancroft, H.: Introduction to Biostatics, Hoeber Medical Division, Harper and Row, New York, 1963, p. 172.Google Scholar
- 12.Gordon, P.: Procainamide: Enhancement of learning covariant with a perturbed amino acid metabolism, Fed. Proc. 26:614, 1967.Google Scholar
- 14.Verzar, F., and McDougall, J.: Learning and memory tests in young and old rats, in: Third Cong. Int. Assoc. Geront., London, 1954, and Old Age in the Modern World, E. & S. Livingstone Ltd., London, 1955, p. 247.Google Scholar
- 15.Hebb, D.O.: The Organization of Behavior: A Neuropsychological Theory, Wiley, New York, 1949.Google Scholar
- 16.Perry, R.P.: The nucleolus and the synthesis of ribosomes, in: David, J.N., and Conn, E. (eds.), Progress in Nucleic Acid Research and Molecular Biology, Vol. 6, Academic Press, New York, 1967, p. 220.Google Scholar
- 17.Watson, J.D.: The Molecular Biology of the Gene, W.A. Benjamin, New York, 1965, p. 85.Google Scholar