Diphenylhydantoin and Procainamide: Normalization of Suboptimal Learning Behavior

  • Paul Gordon


In this paper we explore positive drug effects on the learning behavior of two classes of rats characterized by learning deficit—the aged rat and the young adult rat made deficient by a procedure involving the intraperitoneal injection of 10–20% body weight of 5.5% dextrose, originally developed by Darrow and Yannet [1]. This procedure lowers the electroconvulsive-shock threshold, while increasing brain intracellular water and sodium and decreasing total brain electrolytes [2]. Because of their lowered electroconvulsive-shock threshold, rats so treated have been used to evaluate anticonvulsant drugs [2]. That animals so treated also manifest a learning deficit represents a new finding of our laboratory. It will be specifically shown that these animals reflect aspects of the deficit that develops with aging, thereby constituting a limited model for this condition.


Aged Animal Acquisition Trial Neuronal Hyperexcitability Magnesium Pemoline Shock Frequency 
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  1. 1.
    Darrow, D.C., and Yannet, H.: Changes in distribution of body water accompanying increase and decrease in extracellular electrolyte, J. Clin. Investigation 14:266, 1955.CrossRefGoogle Scholar
  2. 2.
    Thoman, J.E.P., and Goodman, L.S.: Conditions modifying convulsions in animals, in: Proceedings of Association for Research inNervous and Mental Disease, Vol. 36, 1946, p. 141.Google Scholar
  3. 3.
    Welford, A.T.: Performance, biological mechanisms and age: A theoretical sketch, in: Welford, A.T., and Birren, J.E. (eds.), Behavior, Aging, and the Nervous System, Charles Thomas, Springfield, 1965, p. 3.Google Scholar
  4. 4.
    Inglis, J.: Immediate memory. Age and Brain Function; in: Welford, A.T., and Birren, J.E. (eds.), Behavior, Aging and the Nervous System, Charles Thomas, Springfield, 1965, p. 88.Google Scholar
  5. 5.
    Mundy-Castle, A.C.: An analysis of central responses to the photic stimulation in normal adults, EEG Clin. Neurophysiol. 5:1, 1953.CrossRefGoogle Scholar
  6. 6.
    Axelrod, S.: Cognitive tasks in several modalities, in: Williams, R.H., Tibbits, C., and Donahue, W. (eds.), Processes of Aging, Vol. 1, Atherton Press, New York, 1963, p. 132.Google Scholar
  7. 7.
    Plotnikoff, N.: Magnesium pemoline: Enhancement of learning and memory of a conditioned avoidance response, Science 151:703, 1966.PubMedCrossRefGoogle Scholar
  8. 8.
    Bancroft, H.: Introduction to Biostatics, Hoeber Medical Division, Harper and Row, New York, 1963, p. 172.Google Scholar
  9. 9.
    Schneider, W.C.: Phosphorus compounds in animal tissues. I. Extraction and estimation of deoxypentose nucleic acid and of pentose nucleic acid, J. Biol. Chem. 161:293, 1945.PubMedGoogle Scholar
  10. 10.
    Pisano, J.J., Wilson, J.D., Cohen, L., Abraham, D., and Udenfriend, S.: Isolation of amino-butyryhistidine (homocarnosine) from brain, J. Biol. Chem. 236:499, 1961,PubMedGoogle Scholar
  11. 11.
    Waalkes, T.P., and Udenfriend, S.: A fluorimetric method for the estimation of tyrosine in plasma and tissues, J. Lab. Clin. Med. 50:733, 1957.PubMedGoogle Scholar
  12. 12.
    Gordon, P.: Procainamide: Enhancement of learning covariant with a perturbed amino acid metabolism, Fed. Proc. 26:614, 1967.Google Scholar
  13. 13.
    Doty, B.A.: Age and avoidance conditioning, J. Geront. 21:287, 1966.PubMedCrossRefGoogle Scholar
  14. 14.
    Verzar, F., and McDougall, J.: Learning and memory tests in young and old rats, in: Third Cong. Int. Assoc. Geront., London, 1954, and Old Age in the Modern World, E. & S. Livingstone Ltd., London, 1955, p. 247.Google Scholar
  15. 15.
    Hebb, D.O.: The Organization of Behavior: A Neuropsychological Theory, Wiley, New York, 1949.Google Scholar
  16. 16.
    Perry, R.P.: The nucleolus and the synthesis of ribosomes, in: David, J.N., and Conn, E. (eds.), Progress in Nucleic Acid Research and Molecular Biology, Vol. 6, Academic Press, New York, 1967, p. 220.Google Scholar
  17. 17.
    Watson, J.D.: The Molecular Biology of the Gene, W.A. Benjamin, New York, 1965, p. 85.Google Scholar

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© Springer Science+Business Media New York 1968

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  • Paul Gordon

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