Cellular and Genetic Basis of the Relative Resistance to the Induction of Experimental Allergic Encephalomyelitis (EAE) in Albino Oxford (AO) Rats

  • Marija Mostarica-Stojkovic
  • Milica Petrovic
  • Miodrag L. Lukic
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


EAE has been widely studied as a possible model for human demyelinative disease. It can be readily induced in several strains of rats by a single injection of spinal cord or encephalitogenic basic protein emulsified in complete Freund’s adjuvant (CFA). We have previously reported that AO rats always exhibited significantly lower susceptibility to the induction of EAE when compared with Lewis rats (1). In an attempt to delineate the mechanisms of the relative resistance to the induction of EAE in AO rats we studied comparatively the cellular requirements for the induction of EAE in Lewis, AO and Dark August (DA) rats. Further, we have undertaken a study of susceptibility to EAE in AO and DA rats, their F1 hybrids and animals of backcross generations in order to establish possible genetic determinants of the resistance to EAE in AO rats.


Basic Protein Experimental Allergic Encephalomyelitis Relative Resistance Backcross Generation Suppressor Cell Activity 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Marija Mostarica-Stojkovic
    • 1
  • Milica Petrovic
    • 1
  • Miodrag L. Lukic
    • 1
  1. 1.Institute of Microbiology and Immunology, School of Medicine, Institute of Physiology, School of Pharmacy and Laboratory for Cellular ImmunologyInstitute for Biological ResearchBelgradeYugoslavia

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