Secondary in Vivo Cytotoxic T Cell Responses to Minor Histocompatibility Antigens

  • C. E. M. Sharrock
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


Cytotoxic T cell responses towards cells carrying foreign minor histocompatibility antigens have been shown to be H-2 restricted in their effector function (1). The T cell interactions required to generate both primary and secondary responses to such antigens have not yet been fully defined. Indication that T cell help is required for the induction of cytotoxic T cells against the minor antigen H-Y has been found in radiation chimeras (2). The following study has established a suitable system for determinating the nature of T cell interactions in vivo when responses are made to both multiple and single minor antigens.


Spleen Cell Effector Function Adoptive Transfer Spontaneous Release Peritoneal Cell 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • C. E. M. Sharrock
    • 1
  1. 1.Imperial Cancer Research Fund Tumour Immunology Unit, Department of ZoologyUniversity College LondonLondonUK

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