Impaired Host Resistance Against Local JMV Marek’s Disease Tumors after Thymectomy and After Bursectomy

  • K. M. Lam
  • T. J. Linna
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


It has been well established that the immune system of the chicken displays a dichotomy of responsiveness. Thymectomy in the newly-hatched period, combined with sublethal irradiation, has been demonstrated to significantly impair cell-mediated immunological functions (Cooper et al., 1966). Surgical bursectomy in the newly-hatched period impairs antibody-forming capacity (Glick et al., 1956). Treatment with high doses of cyclophosphamide during the first days of life results in a more profound, selective deficiency of the bursa-dependent, antibody-forming system in month-old or older animals (Lerman and Weidanz, 1970; Linna et al., 1972). The delineation of immunological responsiveness in the chicken can be used to study the influences of cell-mediated immunity, and of the antibody-forming system on tumor development.


Tumor Bearer Cyclophosphamide Treatment Fisher Exact Probability Test Sublethal Irradiation Virus Tumor Induction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Calnek, B. W., Fabricant, J., Schat, K. A., and Murthy, K. K., 1978, Rejection of a transplantable Marek’s disease lymphoma in normal versus immunologically deficient chickens, J. Natl. Cancer Inst., 60:623.PubMedGoogle Scholar
  2. Cooper, M. D., Peterson, R. D. A., South, M. A., and Good, R. A., 1966, The functions of the thymus system and the bursa system in the chicken, J. Exp. Med., 123:75.PubMedCrossRefGoogle Scholar
  3. Glick, B., Chang, T. S., and Jaap, R. G., 1956, The bursa of Fabricius and antibody production, Poult. Sci., 35:224.CrossRefGoogle Scholar
  4. Herberman, R. B., Nunn, M. E., and Lavrin, D. H., 1975, Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificity, Int. J. Cancer, 16:216.PubMedCrossRefGoogle Scholar
  5. Hu, C.-P., and Linna, T. J., 1976, Serotherapy of avian reticuloendotheliosis virus-induced tumors, Ann. NY Acad. Sci., 277:634.PubMedCrossRefGoogle Scholar
  6. Hudson, L., and Payne, L. N., 1973, An analysis of the T and B cells in Marek’s disease lymphomas of the chicken, Nature (London), 241:152.Google Scholar
  7. Kiessling, R., Klein, E., Pross, H., and Wigzell, H., 1975, “Natural” killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cell, Eur. J. Immunol., 5:117.PubMedCrossRefGoogle Scholar
  8. Lam, K. M. , and Linna, T. J., 1976, Impaired host defense against XC-cell-induced tumors in thymectomized and in bursectomized chickens, Cancer Res., 36:1710.PubMedGoogle Scholar
  9. Lam, K. M., and Linna, T. J., 1978, Protection of newly-hatched chickens from Marek’s disease (JMV) by normal spleen cells from older animals, in: “Advances in Comparative Leukemia Research, 1977,” P. Bentvelzen, J. Hilgers, and D. S. Yohn, ed., Elsevier/ North Holland Biomedical Press, Amsterdam.Google Scholar
  10. Lam, K. M., and Linna, T. J., 1979, Transfer of natural resistance to Marek’s disease (JMV) with non-immune spleen cells. I. Studies of cell population transferring resistance, Int. J. Cancer, 24:662.PubMedCrossRefGoogle Scholar
  11. Lam, K. M., and Linna, T. J., 1980, Transfer of natural resistance to Marek’s disease (JMV) with non-immune spleen cells. II. Further characterization of protecting cell population, J. Immunol., 125:715.PubMedGoogle Scholar
  12. Lerman, S. P., Palladino, M. A., and Thorbecke, G. J., 1976, Chemical carcinogen-induced transplantable fibrosarcomas in histocompatible chickens. I. Incidence of tumor induction in normal and bursectomized chickens, J. Natl. Cancer Inst., 57:295.PubMedGoogle Scholar
  13. Lerman, S. P., and Weidanz, W. P., 1970, The effect of cyclophosphamide on the ontogeny of the humoral immune response in chickens, J. Immunol., 105:614.PubMedGoogle Scholar
  14. Linna, T. J., 1976, Increased growth rate of Benzo(a)pyrene-induced transplantable tumors in bursectomized chicks, Cancer Res., 36:1705.PubMedGoogle Scholar
  15. Linna, T. J., Frommel, D., and Good, R. A., 1972, Effects of early cyclophosphamide treatment on the development of lymphoid organs and immunological functions in the chicken, Int. Arch. Allergy Appl. Immunol., 42:20.PubMedCrossRefGoogle Scholar
  16. Linna, T. J., Hu, C.-P., and Thompson, K. D., 1974, Development of systemic and local tumors induced by avian reticuloendotheliosis virus following thymectomy or bursectomy, J. Natl. Cancer Inst., 53:847.PubMedGoogle Scholar
  17. Payne, L. N., 1972, Pathogenesis of Marek’s disease — A review, in: “Oncogenesis and Herpesviruses,” P. M. Biggs, G. de-Thd, and L. N. Payne, ed., IARC, Lyon.Google Scholar
  18. Radzichovskaja, R., 1967a, Effect of bursectomy on the Rous virus tumor induction in chickens, Nature, 213:1258.CrossRefGoogle Scholar
  19. Radzichovskaja, R., 1967b, Effect of thymectomy on Rous virus tumor growth induced in chickens, Proc. Soc. Exp. Biol. Med., 126:13.Google Scholar
  20. Sevoian, M., Larose, R. N., and Chamberlain, D. M., 1964, Avian lymphomatosis: increased pathogenicity of JM virus, Proc. 101st Annu. Meet. Am. Vet. Med. Assn., Chicago, p. 342.Google Scholar
  21. Sharma, J. M., Nazerian, K., and Witter, R. L., 1977, Reduced incidence of Marek’s disease gross lymphomas in T-cell depleted chickens, J. Natl. Cancer Inst., 56:698.Google Scholar
  22. Shieh, J. M., and Sevoian, M., 1975, The influence of humoral and cell-mediated immunity in Marek’s disease (MD) infection, Abstr. Annu. Meet. Am. Soc. Microbiol., p. 75.Google Scholar
  23. Spencer, J. L., Gavora, J. S., Hare, W. C. D., Grunder, A. A., Robertson, A., and Speckmann, G. W., 1976, Studies on genetic resistance and on vaccination-induced resistance of chickens to lymphoid tumor transplants. I. Marek’s tumor transplant (JMV), Avian Dis., 20:268.PubMedCrossRefGoogle Scholar
  24. Stephens, E. A., Witter, R. L., Lee, L. F., Sharma, J. M., Nazerian, K., and Longenecker, B. M., 1976, Characteristics of JMV Marek’s disease tumor: A nonproductively infected transplantable cell lacking in rescuable virus, J. Natl. Cancer Inst., 57:865.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • K. M. Lam
    • 1
  • T. J. Linna
    • 1
  1. 1.Department of Microbiology and ImmunologyTemple University School of MedicinePhiladelphiaUSA

Personalised recommendations