Autoimmune Disease Strongly Resembling Systemic Lupus Erythematosus (SLE) in F1 Mice Undergoing Graft-Versus-Host Reaction (GVHR)
The etiology and cellular pathogenesis of human SLE and of the spontaneously arising SLE-like diseases of mice are still poorly understood. Especially, the possible participation of T helper (TH) cells and, if this exists, the mode of action by which it causes the formation of multiple IgG autoantibodies is unclear (1). There is general agreement, however, that in both SLE and SLE-like conditions there is a B-cell hyperactivity (1), which has sometimes been referred to as “polyclonal” B-cell stimulation (2). Since potentially autoreactive B cells exist in normal individuals (3), they might be switched on to antibody production in states of generalized B-cell hyperactivity. Indeed, it has been possible to induce the formation of various SLE-like autoantibodies in nonautoimmune strains of mice by the administration of the polyclonal B-cell activator lipopolysaccharide (LPS) (4,5). However, there are no reports which indicate that LPS can induce the severe clinical and pathological alterations characteristic of SLE. Moreover, there is no evidence suggesting that human SLE patients are exposed to an abnormal load of bacterial products capable of inducing polyclonal B-cell stimulation.
KeywordsSystemic Lupus ERYTHEMATOSUS Nuclear Antigen Optimal Induction Human Systemic Lupus ERYTHEMATOSUS Cellular Pathogenesis
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- 3.A.C. Allison, in: “Autoimmunity”, N. Talal, ed. Academic Press, Inc., New York (1977).Google Scholar
- 6.P.J. Fialkow, C. Gilchrist, and A.C. Allison. Clin. Exp. Immunol. 12:479 (1973).Google Scholar
- 8.J.P.W. van der Veen, A.G. Rolink, and E. Gleichmann. J. Immunol. 127 (1981) in press.Google Scholar
- 9.E.H. van Elven, A.G. Rolink, F.M. van der Veen, Ph. Issa, Th. M. Duin, and E. Gleichmann. Submitted.Google Scholar
- 13.S.T. Pals, T. Radaszkiewicz, and E. Gleichmann. This volume.Google Scholar
- 14.D.H. Katz, in : “Lymphocyte Differentiation, Recognition and Regulation”, p. 482, Academic Press, Inc., New York (1977).Google Scholar
- 16.E. Gleichmann, and H. Gleichmann, in: “Immunoregulation and Autoimmunity”, R.S. Krakauer and M.K. Cathcart, eds. p. 73, Elsevier North Holland, Inc., New York (1980).Google Scholar
- 17.H. Gleichmann, S.T. Pals, T. Radaszkiewicz, and M. Wasser. This volume.Google Scholar
- 18.L.A. Aarden, and R. Smeenk, in: “Immunological Methods”, Vol. II, I. Lefkovits, ed. , p. 75, Academic Press, New York (1981).Google Scholar
- 23.G.G.B. Klaus, in: “B and T Cells in Immune Recognition”, F. Loor and G.E. Roelants, eds., p. 235, John Wiley and Sons, Chicester (1977).Google Scholar
- 26.J. Andersson, and F. Melchers, in: “B Lymphocytes in the Immune Response”, N. Klinman, D.E. Mosier, I. Scher, and S. Vitetta, eds., Elsevier North Holland, New York, in press.Google Scholar