Cell-Interactions in the Splenic Suppression Caused by Antigen-Feeding

  • Thomas T. MacDonald
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


Whereas antigen given systemically usually results in a humoral or cell-mediated immune response, antigen given by the oral route usually induces a state of tolerance (1–4). This is most often demonstrated by a reduced response to systemic antigen challenge given after the initial oral antigen administration. Several investigators have shown that the unresponsive state induced by antigen-feeding is “infectious,” that is infusion of cells from antigen-fed mice into normal recipients transfers the unresponsive state (4–6). These data would seem to indicate that antigen-feeding induces suppressor T cells, but in the light of recent findings on T cell interactions, other explanations are available; the main one of which is that antigen-feeding does not induce suppressor T cells, but instead produces “suppressor-inducers” (7, 8). These cells, when re-exposed to antigen can co-opt other T cells to become suppressor cells.


Spleen Cell Suppressor Cell Jefferson Medical College Spleen Cell Culture Normal Spleen Cell 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Thomas T. MacDonald
    • 1
  1. 1.Department of MicrobiologyJefferson Medical CollegePhiladelphiaUSA

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