Nonspecific Suppression of Anti-Graft Immunity by Antigen-Specific T Suppressor Cells

  • A. T. J. Bianchi
  • L. M. Hussaarts-Odijk
  • R. Benner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


The specificity of T suppressor cells induced by intravenous administration of irradiated allogeneic spleen cells was studied in mice by means of a delayed type hypersensitivity (DTH) assay. T suppressor cells induced by either H-2K, H-2I or H-2D incompatible cells were found to be specific for the inducing alloantigen. Such antigen specific T suppressor cells can suppress the response to another H-2 alloantigen, provided it is administered together with the alloantigen that had induced the T suppressor cells. Similarly, T suppressor cells induced by non-H-2 alloantigens can suppress the response to H-2 alloantigens if administered simultaneously.


Spleen Cell Suppressor Cell Delay Type Hypersensitivity Nonspecific Suppression Delay Type Hypersensitivity Reactivity 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • A. T. J. Bianchi
    • 1
  • L. M. Hussaarts-Odijk
    • 1
  • R. Benner
    • 1
  1. 1.Department of Cell Biology and GeneticsErasmus UniversityRotterdamThe Netherlands

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