Nonspecific Suppression of Anti-Graft Immunity by Antigen-Specific T Suppressor Cells
The specificity of T suppressor cells induced by intravenous administration of irradiated allogeneic spleen cells was studied in mice by means of a delayed type hypersensitivity (DTH) assay. T suppressor cells induced by either H-2K, H-2I or H-2D incompatible cells were found to be specific for the inducing alloantigen. Such antigen specific T suppressor cells can suppress the response to another H-2 alloantigen, provided it is administered together with the alloantigen that had induced the T suppressor cells. Similarly, T suppressor cells induced by non-H-2 alloantigens can suppress the response to H-2 alloantigens if administered simultaneously.
KeywordsSpleen Cell Suppressor Cell Delay Type Hypersensitivity Nonspecific Suppression Delay Type Hypersensitivity Reactivity
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