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Human Sessile B Lymphocyte Marker Defined by a Monoclonal Antibody

  • H. K. Forster
  • F. Suter
  • F. G. Gudat
  • J. P. Obrecht
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)

Abstract

Human B or T lymphocytes from peripheral blood (PBL) are identified by the presence of surface immunoglobulin or receptors for sheep erythrocytes (SE). The availability of monoclonal antibodies recently allowed a correlation of T cell surface markers with T cell effector functions (Reinherz and Schlossman, 1980) and, additionally a description of T cell intrathymic differentiation stages in man. In contrast, the description of human B cell differentiation is based on the appearance of surface Ig molecules (sIg) and complement receptors. We present evidence for the existence of a cell membrane marker on those B lymphocytes which are associated with solid lymphoid tissues (“sessile B lymphocytes”).

Keywords

Chronic Lymphocytic Leukemia Secondary Lymphoid Organ Sheep Erythrocyte Rosette Formation Daudi Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • H. K. Forster
    • 1
  • F. Suter
    • 1
  • F. G. Gudat
    • 1
  • J. P. Obrecht
    • 1
  1. 1.Pharma Research Dept. F. Hoffmann-La Roche, Institute for Pathology, Oncology Unit KantonsspitalUniversity of BaselBaselSwitzerland

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