Human Sessile B Lymphocyte Marker Defined by a Monoclonal Antibody

  • H. K. Forster
  • F. Suter
  • F. G. Gudat
  • J. P. Obrecht
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


Human B or T lymphocytes from peripheral blood (PBL) are identified by the presence of surface immunoglobulin or receptors for sheep erythrocytes (SE). The availability of monoclonal antibodies recently allowed a correlation of T cell surface markers with T cell effector functions (Reinherz and Schlossman, 1980) and, additionally a description of T cell intrathymic differentiation stages in man. In contrast, the description of human B cell differentiation is based on the appearance of surface Ig molecules (sIg) and complement receptors. We present evidence for the existence of a cell membrane marker on those B lymphocytes which are associated with solid lymphoid tissues (“sessile B lymphocytes”).


Chronic Lymphocytic Leukemia Secondary Lymphoid Organ Sheep Erythrocyte Rosette Formation Daudi Cell 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • H. K. Forster
    • 1
  • F. Suter
    • 1
  • F. G. Gudat
    • 1
  • J. P. Obrecht
    • 1
  1. 1.Pharma Research Dept. F. Hoffmann-La Roche, Institute for Pathology, Oncology Unit KantonsspitalUniversity of BaselBaselSwitzerland

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