Human Sessile B Lymphocyte Marker Defined by a Monoclonal Antibody
Human B or T lymphocytes from peripheral blood (PBL) are identified by the presence of surface immunoglobulin or receptors for sheep erythrocytes (SE). The availability of monoclonal antibodies recently allowed a correlation of T cell surface markers with T cell effector functions (Reinherz and Schlossman, 1980) and, additionally a description of T cell intrathymic differentiation stages in man. In contrast, the description of human B cell differentiation is based on the appearance of surface Ig molecules (sIg) and complement receptors. We present evidence for the existence of a cell membrane marker on those B lymphocytes which are associated with solid lymphoid tissues (“sessile B lymphocytes”).
KeywordsChronic Lymphocytic Leukemia Secondary Lymphoid Organ Sheep Erythrocyte Rosette Formation Daudi Cell
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