The Role of I-J Subregion Gene Products in the Inhibition of Delayed-Type Hypersensitivity to Major Histocompatibility Antigens by Specific Suppressor T Cells

  • F. Y. Liew
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


Different subsets of T lymphocytes appear to be restricted in their effector function by distinct major-histocompatibility gene products. H-2K or D molecules (class I determinants) are recognized by cytotoxic T cells (Tc) (1–3) and H-2I molecules (class II determinants) by T-helper cells (Th) (4) or T cells mediating delayed-type hypersensitivity (Td) (5). Recent evidence suggests that the class II determinants should be further subdivided. The I-A and I-E/C subregion products are associated with Th and Td cells, while I-J molecules are preferentially recognized by the various antigen-specific suppressor cells or their products (6–9).


Spleen Cell Associative Recognition Adoptive Cell Transfer Challenge Cell Major Histocompatibility Antigen 
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  1. 1.
    R.M. Zinkernagel, and P.C. Doherty. Nature 248:701 (1974).PubMedCrossRefGoogle Scholar
  2. 2.
    G.M. Shearer. Eur. J. Immunol. 4:527 (1974).PubMedCrossRefGoogle Scholar
  3. 3.
    M.J. Bevan. J. Exp. Med. 142:1349 (1975).PubMedCrossRefGoogle Scholar
  4. 4.
    D.H. Katz, M. Graves, M.E. Dorf, H. DiMuzio, and B. Benacerraf. J. Exp. Med. 141:263 (1975).PubMedCrossRefGoogle Scholar
  5. 5.
    J.F.A.P. Miller, M.A. Vadas, A. Whitelaw, and J. Gamble. Proc. Natl. Acad. Sci. USA 79:5095 (1975).CrossRefGoogle Scholar
  6. 6.
    F.H. Bach, C. Grillot-Courvalin, O.J. Kuperman, H.W. Sollinger, C. Hayes, P.M. Sondei, B.J. Alter, and M.L. Bach. Immunol. Rev. 35:76 (1977).PubMedCrossRefGoogle Scholar
  7. 7.
    J.W. Streilein. Immunol. Rev. 46:125 (1979).CrossRefGoogle Scholar
  8. 8.
    R.M. Zinkernagel. Immunogenetics 10:373 (1980).PubMedCrossRefGoogle Scholar
  9. 9.
    A.A. Czitrom, G.H. Sunshine, and N.A. Mitchison. Immunogenetics 11:97 (1980).PubMedCrossRefGoogle Scholar
  10. 10.
    F.Y. Liew. Eur. J. Immunol. (1981) in press.Google Scholar
  11. 11.
    T. Tada, and K. Okumura. Adv. Immunol. 28:1 (1980).CrossRefGoogle Scholar
  12. 12.
    F.Y. Liew, and E. Simpson. Immunogenetics 11:255 (1980).PubMedCrossRefGoogle Scholar
  13. 13.
    B.E. Loveland, P.M. Hogarth, R.H. Ceredig, and I.F.C. McKenzie. J. Exp. Med. 153:1044 (1981).PubMedCrossRefGoogle Scholar
  14. 14.
    F.E.G. Cox. Nature 291:111 (1981).PubMedCrossRefGoogle Scholar
  15. 15.
    V. Holan, and M. Hasek. Immunogenetics 12:465 (1981).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • F. Y. Liew
    • 1
  1. 1.Department of Experimental ImmunobiologyThe Wellcome Research LaboratoriesBeckenham, KentUK

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