The Role of I-J Subregion Gene Products in the Inhibition of Delayed-Type Hypersensitivity to Major Histocompatibility Antigens by Specific Suppressor T Cells
Different subsets of T lymphocytes appear to be restricted in their effector function by distinct major-histocompatibility gene products. H-2K or D molecules (class I determinants) are recognized by cytotoxic T cells (Tc) (1–3) and H-2I molecules (class II determinants) by T-helper cells (Th) (4) or T cells mediating delayed-type hypersensitivity (Td) (5). Recent evidence suggests that the class II determinants should be further subdivided. The I-A and I-E/C subregion products are associated with Th and Td cells, while I-J molecules are preferentially recognized by the various antigen-specific suppressor cells or their products (6–9).
KeywordsSpleen Cell Associative Recognition Adoptive Cell Transfer Challenge Cell Major Histocompatibility Antigen
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