Induction and Suppression of Delayed-Type Hypersensitivity to Sheep Red Blood Cells by Anti-Idiotypic Antiserum
Immune responses are regulated by complex interactions between cells and humoral factors (1). In the sheep red blood cell (SRBC) model, it has been shown that low doses of antigen are optimal for delayed-type hypersensitivity (DTH) whereas high doses of SRBC preferably induce humoral immunity and concomitantly lead to suppression of DTH which, at least in part, is due to activation of suppressor T cells (2,3). As another candidate for regulatory mechanisms, anti-idiotypic antibodies (a-Id) have been proposed (4). In the present paper we show that administration of a-Id against anti-SRBC-antibodies allows to markedly influence the cellular immune response to this multideterminant antigen in a positive and negative way.
KeywordsSpleen Cell Cellular Immune Response Recipient Mouse Donor Mouse Challenge Control
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