Advertisement

Induction and Suppression of Delayed-Type Hypersensitivity to Sheep Red Blood Cells by Anti-Idiotypic Antiserum

  • S. H. E. Kaufmann
  • H. Hahn
  • R. K. Gershon
  • G. M. Iverson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)

Abstract

Immune responses are regulated by complex interactions between cells and humoral factors (1). In the sheep red blood cell (SRBC) model, it has been shown that low doses of antigen are optimal for delayed-type hypersensitivity (DTH) whereas high doses of SRBC preferably induce humoral immunity and concomitantly lead to suppression of DTH which, at least in part, is due to activation of suppressor T cells (2,3). As another candidate for regulatory mechanisms, anti-idiotypic antibodies (a-Id) have been proposed (4). In the present paper we show that administration of a-Id against anti-SRBC-antibodies allows to markedly influence the cellular immune response to this multideterminant antigen in a positive and negative way.

Keywords

Spleen Cell Cellular Immune Response Recipient Mouse Donor Mouse Challenge Control 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    H. Cantor, and R.K. Gershon. Fed. Proc. 38:2058 (1979).PubMedGoogle Scholar
  2. 2.
    I.A. Ramshaw, P.A. Bretscher, and C.R. Parish. Eur. J. Immunol. 6:674 (1974).CrossRefGoogle Scholar
  3. 3.
    S.H.E. Kaufmann, J.S. Ahmed, M. Chahin, and H. Hahn. Immunology 38:613 (1979).PubMedGoogle Scholar
  4. 4.
    N.K. Jerne. Eur. J. Immunol. 1:1 (1971).PubMedCrossRefGoogle Scholar
  5. 5.
    F.W. Shen, E.A. Boyse, and H. Cantor. Immunogenetics 2:591 (1975).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • S. H. E. Kaufmann
    • 1
  • H. Hahn
    • 1
  • R. K. Gershon
    • 2
  • G. M. Iverson
    • 2
  1. 1.Institute for Medical MicrobiologyFree University of BerlinGermany
  2. 2.Department of PathologyYale UniversityNew HavenUSA

Personalised recommendations