Negative Selection of Discrete Subgroups of T Helper Cells Restricted by Determinants Present on I-A and I-A/E Molecules
When T cells encounter antigen in vivo, the responding cells leave the recirculating lymphocyte pool, e.g., thoracic duct lymph (TDL), and become temporarily sequestered in regions of antigen localization, particularly the spleen (1). A similar sequence of events occurs if purified T cells are exposed to antigen [sheep erythrocytes (SRC)] after adoptive transfer into heavily irradiated mice (2). In this situation the SRC-specific donor T cells are not detectable in TDL of the host for 1–2 d post-transfer (negative selection) but thereafter enter the lymph in large numbers as activated T helper cells (positive selection).
KeywordsNegative Selection Helper Cell Adoptive Transfer Cell Surface Expression Discrete Subgroup
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- 6.P.P. Jones, D.B. Murphy, and H.O. McDevitt, in: “Ir Genes and Ia Antigens,” p. 203, H.O. McDevitt, ed., Academic Press, New York (1978).Google Scholar