Negative Selection of Discrete Subgroups of T Helper Cells Restricted by Determinants Present on I-A and I-A/E Molecules

  • Barbara Alpert
  • J. Sprent
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


When T cells encounter antigen in vivo, the responding cells leave the recirculating lymphocyte pool, e.g., thoracic duct lymph (TDL), and become temporarily sequestered in regions of antigen localization, particularly the spleen (1). A similar sequence of events occurs if purified T cells are exposed to antigen [sheep erythrocytes (SRC)] after adoptive transfer into heavily irradiated mice (2). In this situation the SRC-specific donor T cells are not detectable in TDL of the host for 1–2 d post-transfer (negative selection) but thereafter enter the lymph in large numbers as activated T helper cells (positive selection).


Negative Selection Helper Cell Adoptive Transfer Cell Surface Expression Discrete Subgroup 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Barbara Alpert
    • 1
  • J. Sprent
    • 1
  1. 1.Division of Research Immunology, Department of PathologyUniversity of Pennsylvania and the Wistar InstitutePhiladelphiaUSA

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