Systemic Immunomodulation Induced by a “Loco-Regional” GVHR in the Rat

  • P. Lang
  • B. Charpentier
  • N. Cividino
  • D. Fries
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


Since its initial description (1–3), popliteal lymph node assay (PLN assay) in rats has long been considered to be a “loco-regional” form of graft-versus-host reaction (GVHR). Recently Grebe and Streilein have demonstrated the existence of a systemic component expressed mainly by splenomegaly and distant lympha-denopathy (4). If the assay has a widely disseminated expression, it should be possible to detect an immunomodulation identical to the regulatory mechanisms arising during a classic systemic GVH (GVH disease, GVHD), such as the survival and recovery of the host, and the refractoriness to a new specific or nonspecific challenge (5–7) (GVHR resistance). In this report, the possible systemic GVHR resistance induced by a PLN assay has been tested in two models of GVHR: GVHD, and PLN assay. In this latter model the first GVHR was induced on one hind footpad whereas the challenge inoculum was performed on the controlateral footpad.


Spleen Cell Lymphoid Cell Initial Description Immunologic Status Distant Lympha 
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  1. 1.
    S. Levine. Transplantation 6:799 (1968).PubMedCrossRefGoogle Scholar
  2. 2.
    W.L. Ford, W. Burr, and M. Simonsen. Transplantation 10:258 (1970).PubMedCrossRefGoogle Scholar
  3. 3.
    V. Haskova, and E. Gansova. Folia Biol. 16:314 (1970).Google Scholar
  4. 4.
    S.C. Grebe, and J.W. Streilein. Transplantation 22:245 (1976).PubMedCrossRefGoogle Scholar
  5. 5.
    E.O. Field, and J.E. Gibbs. Clin. Exp. Immunol. 1:195 (1966).PubMedGoogle Scholar
  6. 6.
    J.W. Streilein. J. Exp. Med. 135:567 (1972).PubMedCrossRefGoogle Scholar
  7. 7.
    M. Fox., J.G. Howard. Transplantation 1:1 (1963).CrossRefGoogle Scholar
  8. 8.
    Ph. Lang, B. Charpentier, B. Martin, N. Cividino, and D. Fries. Transplant. Proc. 13:1 226 (1981).Google Scholar
  9. 9.
    P. Mccullagh. Austr. J. Biol. Med. Sci. 51:753 (1973).CrossRefGoogle Scholar
  10. 10.
    M.W. Elves. Transplantation 16:403 (1973).PubMedCrossRefGoogle Scholar
  11. 11.
    N.R. Rose. Transplantation 20:248 (1975).PubMedCrossRefGoogle Scholar
  12. 12.
    R.T. Woodland, and D.B. Wilson. Eur. J. Immunol. 7:136 (1977).PubMedCrossRefGoogle Scholar
  13. 13.
    D. Bellgrau, and D.B. Wilson. J. Exp. Med. 148:103 (1978).PubMedCrossRefGoogle Scholar
  14. 14.
    J.R. Markwick, and G.D. Pergrum. Cell. Immunol. 45:452 (1979).PubMedCrossRefGoogle Scholar
  15. 15.
    D. Steinmuller. Transplantation 30:313 (1980).PubMedCrossRefGoogle Scholar
  16. 16.
    M.N. Cauchi, and K.B. Dawson. J. Exp. Med. 142:248 (1975).PubMedCrossRefGoogle Scholar
  17. 17.
    T.J. McKearn, Y. Hamada, F.P. Stuart, and F.W. Fitch. Nature 251:648 (1974).PubMedCrossRefGoogle Scholar
  18. 18.
    S.C. Grebe, and J.W. Streilein. Adv. Immunol. 22:119 (1976).PubMedCrossRefGoogle Scholar
  19. 19.
    F.L. Shands. Int. J. Immunopharmac. 1:165 (1979).CrossRefGoogle Scholar
  20. 20.
    Ph. Lang., B. Charpentier, B. Martin, and D. Fries. (1981) this volume.Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • P. Lang
    • 1
  • B. Charpentier
    • 1
  • N. Cividino
    • 1
  • D. Fries
    • 1
  1. 1.Service de HephrologieHopital Paul BrouseVillejuifFrance

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