Systemic Immunomodulation Induced by a “Loco-Regional” GVHR in the Rat
Since its initial description (1–3), popliteal lymph node assay (PLN assay) in rats has long been considered to be a “loco-regional” form of graft-versus-host reaction (GVHR). Recently Grebe and Streilein have demonstrated the existence of a systemic component expressed mainly by splenomegaly and distant lympha-denopathy (4). If the assay has a widely disseminated expression, it should be possible to detect an immunomodulation identical to the regulatory mechanisms arising during a classic systemic GVH (GVH disease, GVHD), such as the survival and recovery of the host, and the refractoriness to a new specific or nonspecific challenge (5–7) (GVHR resistance). In this report, the possible systemic GVHR resistance induced by a PLN assay has been tested in two models of GVHR: GVHD, and PLN assay. In this latter model the first GVHR was induced on one hind footpad whereas the challenge inoculum was performed on the controlateral footpad.
KeywordsSpleen Cell Lymphoid Cell Initial Description Immunologic Status Distant Lympha
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