Specific Systemic Graft-Versus-Host Resistance: Failure to Induce in Adult F1 Rats Tolerized at Birth to Anti-MHC Receptors on Parental T Cells
The injection of mature thymus derived (T) lymphocytes into recipients unable to reject them often results in a complex syndrome referred to as graft-versus-host (GVH) disease (1). Originally A/B F1 animals, where parents A and B are allogeneic and MHC incompatible, were thought to represent an ideal model system for the study of GVH as they lacked, due to codominant inheritance, the capacity to reject parental skin grafts and presumably parental T lymphocytes. However, Gowans (2) showed that in order to elicit GVH symptoms in F1 rats, large doses of parental lymphocytes were required. Field et al. (3) later reported that F1 rats challenged with nonlethal doses of parental lymphocytes were subsequently refractory to lethal doses. They concluded, following adoptive transfer experiments, that the radioinsensitivity of this GVH resistance (GVHR) was likely due to a humoral component. Ramseier and Lindenmann (4) proposed that F1 animals might recognize as foreign and respond against the receptors on parental lymphocytes specific for F1 alloantigens. This concept of F1 anti-parental receptor immunity was strongly reinforced by McKearn (5) and Binz and Wigzell (6) who reported success in raising F1 antibodies to parental T cell anti-MHC receptors.
KeywordsIdeal Model System Codominant Inheritance Overt Symptom Adoptive Transfer Experiment Neonatal Injection
Unable to display preview. Download preview PDF.