Alterated Immunological Reactivity in Rats Sustaining a Graft-Versus-Host-Reaction (GvHR)
Spontaneous GvHR resolution (1), GvHR resistance (1,2) may be observed following a GvHR performed between a parental strain and the F1 hybrid. These observations suggest regulatory processes that are not easily explained by the usual definition of such a reaction, the attack by donor lymphocytes against recipient histocompatibility antigens, the recipient being immunologically defenseless against the donor for genetic reasons. The discovery of F1 hybrid resistance phenomenon (3), and anti-recognition structures (4) shows that in fact the F1 hybrid possesses genetic material that might be able to react against parental structures. Thus regulatory phenomena arising during a GvHR might come from the host. Regulation from the donor is also possible since grafted cells are heterogeneous and might contain suppressor cells and their precursors known to control numerous immunologic reactions. Finally the development of auto-immune phenomena during a GvHR (5,7) suggests complex immunologic interactions, arguing against the classical definition of GvHR. This present report focuses on the immunoregulatory imbalance observed after a “regional” GvHR assessed by a PLN assay performed in the BN → LBN strain combination of rat. To this end in vitro tests have been performed.
KeywordsParental Strain Spleen Cell Suppressor Cell Immunological Reactivity Mixed Lymphocyte Reaction
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