H-2-Restriction of T Cells Mediating Lethal Graft-Versus-Host-Disease to Minor Histocompatibility Determinants

  • J. Sprent
  • R. Korngold
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


Although the etiology and pathogenesis of graft-versus-host disease (GVHD) continues to excite controversy and speculation, it is now generally accepted that the disease reflects alloaggres-sion mediated by mature post-thymic T cells (1–3). The pioneering studies of Siraonsen (1) established that the most florid forms of GVHD occur when the donor and host differ at the major histocompatibility complex (MHC). In recent years, however, it has become clear that severe and often fatal forms of GVHD occur in MHC-com-patible combinations, e.g. following HLA-matched bone marrow transplantation in man (3). Although the etiology of this form of GVHD is still debated, our own studies in mice suggest that responses to minor histocompatibility antigens (minor HA)4 are the principal cause of the disease, at least in this species (4).


Negative Selection Irradiate Mouse Fatal Form Minor Histocompatibility Antigen Congenic Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    M. Simonsen, Prog. Allergy 6:349 (1962).PubMedGoogle Scholar
  2. 2.
    W.L. Elkins, Prog. Allergy 15:78 (1976).CrossRefGoogle Scholar
  3. 3.
    R.P. Gale, and C.F. Fox, in : “Biology of Bone Marrow Transplantation”, Academic Press, New York (1980).Google Scholar
  4. 4.
    R. Korngold, and J. Sprent. J. Exp. Med. 148:1687 (1978).PubMedCrossRefGoogle Scholar
  5. 5.
    Immunological Reviews, Vol. 42, G. Moller, ed. (1978).Google Scholar
  6. 6.
    P.C. Doherty, and R.M. Zinkemagel. Adv. Immunol. 27:51 (1979).PubMedCrossRefGoogle Scholar
  7. 7.
    M.J. Bevan. J. Exp. Med. 142:1349 (1975).PubMedCrossRefGoogle Scholar
  8. 8.
    R. Komgold, and J. Sprent. J. Exp. Med. 151:1114 (1980).CrossRefGoogle Scholar
  9. 9.
    J. Sprent. Exp. Med. 148:478 (1978).CrossRefGoogle Scholar
  10. 10.
    E. Simpson, and R.D. Gordon. Immunol. Rev. 35:59 (1977).PubMedCrossRefGoogle Scholar
  11. 11.
    H. von Boehmer, and W. Haas. J. Exp. Med. 150:1134 (1979).CrossRefGoogle Scholar
  12. 12.
    H. Wagner, C. Hardt, K. Heeg, K. Pfizenmaier, W. Solbach, R. Bartlett, H. Stockinger, and M. Rollinghoff. Immunol. Rev. 51:215 (1980).PubMedCrossRefGoogle Scholar
  13. 13.
    J.R. Bennink, D.H. Schwartz, and P.C. Doherty. Cell Immunol. 60:347 (1981).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • J. Sprent
    • 1
  • R. Korngold
    • 1
  1. 1.Dept. of Pathology, School of Medicine, and the Wistar InstituteUniversity of PennsylvaniaPhiladephiaUSA

Personalised recommendations