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Unique Functional Characteristics of Mucosal Mast Cells

  • A. D. Befus
  • F. L. Pearce
  • R. Goodacre
  • J. Bienenstock
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)

Abstract

Mast cells have been isolated from the intestine (IMC) of rats previously infected with the nematode, Nippostrongylus brasiliensis. Functional studies on IMC have shown that they are responsive to antigen and possess surface IgE but, in contrast to peritoneal mast cells (PMC), IMC are unresponsive to the basic secretatogues, 48/80 and bee venom peptide 401, and hyporesponsive to ionophores. Furthermore, sodium cromoglycate, AH9679 and theorphylline inhibited secretion by PMC but not IMC, whereas doxantrazole inhibited secretion by both cells. Histochemical investigations established that there is mast cell heterogeneity in the human intestine as well as in the rat. Since GALT and BALT are important in intestinal mastocytosis it is important to determine whether the distinct functional properties of IMC reflect a distinct precursor population, inducer cell, or other factors in GALT or BALT.

Keywords

Mast Cell Lamina Propria Sodium Cromoglycate Peritoneal Mast Cell Mucosal Mast Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • A. D. Befus
    • 1
    • 3
  • F. L. Pearce
    • 1
    • 3
  • R. Goodacre
    • 2
  • J. Bienenstock
    • 1
    • 3
  1. 1.Department of PathologyMcMaster UniversityHamiltonCanada
  2. 2.Department of MedicineMcMaster UniversityHamiltonCanada
  3. 3.Department of ChemistryUniversity CollegeLondonEngland

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