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Preferential Uptake of Soluble Antigen by Respiratory Tract Epithelium Overlying Bronchus-Associated Lymphoid Tissue in the Rat

  • Richard L. Gregson
  • Nigel A. Edmondson
  • Benita Plesch
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)

Summary

Soluble protein antigen (Horseradish peroxidase — HRP) administered to rats intratracheally is predominantly phagocytosed by alveolar macrophages and Type-II pneumonocytes. A proportion, after localization on the lumenal surface of the bronchiolar epithelium is transported across the epithelium via the apical cytoplasm and the intercellular space to the region of the basement membrane. The rate of transfer is faster in the epithelium closer to areas of BALT than elsewhere and in these areas there is further significant penetration below the basement membrane into the BALT tissue to facilitate the contact of antigen and of lymphoid cells. No evidence of alveolar macrophage re-entry to the lymphatic system after phagocytosis of HRP could be seen.

Keywords

Basement Membrane Tight Junction Alveolar Macrophage Lymphoid Cell Soluble Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    K.G. Bensch, E. Dominguez, and A.A. Liebow. Science 157:1204 (1967).PubMedCrossRefGoogle Scholar
  2. 2.
    J. Bienenstock, N. Johnston, and D.Y.E. Perey. Lab. Invest. 28(6):686 (1973).PubMedGoogle Scholar
  3. 3.
    J. Fawell, and D.J. Lewis. Lab. Animais 5:267 (1971).CrossRefGoogle Scholar
  4. 4.
    R.C. Graham, and M.J. Karnovsky. J. Histochem. Cytochem. 14: 291 (1966).PubMedCrossRefGoogle Scholar
  5. 5.
    R.L. Gregson, M.J. Davey, and D.E. Prentice. Lab. Animais 13:237 (1979a).Google Scholar
  6. 6.
    R.L. Gregson, M.J. Davey, and D.E. Prentice. Br. J. Exp. Path. 60:471 (1979b).Google Scholar
  7. 7.
    K. Ono. Anat. Embryol. 151:53 (1977).PubMedCrossRefGoogle Scholar
  8. 8.
    R.L. Owen. Gastroenterology 72:440 (1977).PubMedGoogle Scholar
  9. 9.
    A.S. Simani, S. Inoue, and J.C. Hogg. Lab. Invest. 31(1): 75 (1974).PubMedGoogle Scholar
  10. 10.
    J. Richardson, T. Bouchard, and C.C. Ferguson. Lab. Invest. 35(4):307 (1976).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Richard L. Gregson
    • 1
  • Nigel A. Edmondson
    • 1
  • Benita Plesch
    • 2
  1. 1.Department of PathologyHuntingdon Research CentreHuntingdonUK
  2. 2.Histologisch Laboratorium Faculteit der GeneeskundeVrije UniversiteitAmsterdamNetherlands

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