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Intestinal Mast Cells and Their Relation to Mesenteric Lymph Nodes

  • E. J. Ruitenberg
  • H. K. Pamentier
  • Anneke Elgersma
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)

Abstract

Intestinal infections by parasitic nematodes, including Trichinella spiralis induce a proliferation of the number of mucosal mast cells (MMC) (1–4). These cells differ from connective tissue mast cells in fixation- and staining characteristics as was described for the rat (5) and the mouse (2). This is probably linked with the absence of heparin in the mucosal mast cells (6). On the other hand, they share the presence of anti-IgE binding capacity (7) and an immunologically comparable cell membrane antigen (4). Furthermore, in contrast to connective tissue mast cells, appearance and proliferation of MMC were shown to be thymus-dependent in both mice (2) and rats (3). Yet it is not clear whether the influence of the thymus is based on the release of a hormone-like factor stimulating a precursor cell to differentiate and proliferate in the intestine or elsewhere or on a thymus-dependent cell, which either stimulates or actually is the precursor cell of the MMC. From IgA plasma cells, present in the intestinal mucosa, it has been clearly demonstrated that they follow a specific homing pattern including a passage through the mesenteric lymph node (8,9).

Keywords

Mast Cell Intestinal Mucosa Adult Worm Mesenteric Lymph Node Mucosal Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    M. Murray, H.R.P. Miller, and W.F.H. Jarrett. Lab. Invest. 19:222 (1968).Google Scholar
  2. 2.
    E.J. Ruitenberg, and A. Elgersma. Nature (London) 264:258 (1976).CrossRefGoogle Scholar
  3. 3.
    E.J. Ruitenberg, A. Elgersma, and W. Kruizinga. Int. Archs. Allergy Appl. Immun. 60:302 (1979a).CrossRefGoogle Scholar
  4. 4.
    E.J. Ruitenberg, A. Elgersma, and C.H. J. Lamers, in: “The mast cell, its role in health and disease”, p. 732, J. Pepys and A.M. Edwards, eds., Pitman, London (1979b).Google Scholar
  5. 5.
    L. Enerback. Acta Path. Microbiol. Scand. 66:289 (1966).PubMedGoogle Scholar
  6. 6.
    J. Tas, and G. Berensen. J. Histochem. Cytochem. 25:1058 (1977).PubMedCrossRefGoogle Scholar
  7. 7.
    G. Mayrhofer. J. Histochem. Cytochem. 25:1058 (1977).CrossRefGoogle Scholar
  8. 8.
    A.J. Husband, and J.L. Gowans. J. Exp. Med. 148:1146 (1978).PubMedCrossRefGoogle Scholar
  9. 9.
    J. Bienenstock, and A.D. Befus. Immunology 41:249 (1980).PubMedGoogle Scholar
  10. 10.
    E.J. Ruitenberg, and P.A. Steerenberg. J. Parasitology 60:1056 (1974).CrossRefGoogle Scholar
  11. 11.
    A. Ferguson, and H.R.P. Miller, in: “The mast cell, its role in health and disease”, p. 159, J. Pepys and A.M. Edwards, eds., Pitman, London (1979).Google Scholar
  12. 12.
    R. Keller, H. Cottier, and M.W. Hess. Immunology 27:1019 (1974).Google Scholar
  13. 13.
    A.D. Befus, and J. Bienenstock. Immunology 38:95 (1979).PubMedGoogle Scholar
  14. 14.
    Y. Nawa and H.R.P. Miller. Cell. Immunol 42:225 (1979).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • E. J. Ruitenberg
    • 1
  • H. K. Pamentier
    • 1
  • Anneke Elgersma
    • 1
  1. 1.Laboratory for PathologyNational Institute of Public HealthBilthovenThe Netherlands

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