Macrophages, Langerhans Cells, Interdigitating and Dendritic Accessory Cells: A Summary
Adherent or accessory cells, previously indicated as “A”-cells are of paramount importance in the immune response in vitro as well as in vivo. The nonlymphoid adherent population of peritoneal exudate cells, which have phagocytic properties, comprise the accessory cells which have to be present in lymphoproliferative responses in vitro. Most of these cells were obviously macrophages. However, they constitute a heterogeneous population of cells. It appeared that only a minority (8–15%) of these cells bear the Ia determinants of the immune response gene complex (1) which determines their antigen presenting function. Moreover, macrophages may change their properties in this respect during adhesion in vitro (2).
KeywordsAccessory Cell Mononuclear Phagocyte System Antigen Present Function Peripheral Lymphoid Organ Birbeck Granule
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