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Rat Thymus Micro-Environment: An Ultrastructural and Functional Characterization

  • A. M. Duijvestijn
  • T. Sminia
  • Y. G. Kohler
  • E. M. Janse
  • E. C. M. Hoefsmit
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)

Abstract

The thymus micro-environment triggers and regulates prolifera-tion and differentiation of thymocytes, which give rise to a population of immunocompetent T-lymphocytes in peripheral lymphoid tissue. Histologically and functionally different areas can be distinguished in the thymus. The cortex predominantly comprises closely packed proliferating thymocytes. In the medulla immunocompetent T-lymphocytes are present (1) intermingled with voluminous nonlymphoid cells. This suggests that the thymus is a central lymphoid organ, in which the pathway of thymocyte maturation is from cortex to medulla. However, the thymus medulla has also been suggested to be an area with peripheral lymphoid tissue characteristics (2). This paper draws up ultrastructural and immunological aspects of the rat thymus micro-environment with respect to thymus function.

Keywords

Nonspecific Esterase Outer Cortex Epithelial Compartment Peripheral Lymphoid Tissue Medullary Area 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • A. M. Duijvestijn
    • 1
  • T. Sminia
    • 1
  • Y. G. Kohler
    • 1
  • E. M. Janse
    • 1
  • E. C. M. Hoefsmit
    • 1
  1. 1.Department of Electron Microscopy, Medical FacultyFree UniversityAmsterdamThe Netherlands

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