The Principal Cells in the Thymus Expressing MHC Antigens are Epithelial

  • Robert V. Rouse
  • Irving L. Weissman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


In general, peripheral T cells recognize foreign antigens only in the context of self MHC antigens. This MHC restriction has been shown, at least in some cases, to be determined by radio resistant elements within the thymus (Zinkernagel, 1978). Under some experimental protocols, however, developing T cells acquire instead a preference for bone marrow derived MHC antigens (Katz et al., 1979, Zinkernagel et al., 1980).


Immunoelectron Microscopy Principal Cell Thymic Epithelial Cell Human Thymus Mouse Thymus 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Robert V. Rouse
    • 1
  • Irving L. Weissman
    • 1
  1. 1.Laboratory of Experimental Oncology, Department of PathologyStanford University Medical CenterStanfordUSA

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