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The Principal Cells in the Thymus Expressing MHC Antigens are Epithelial

  • Robert V. Rouse
  • Irving L. Weissman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)

Abstract

In general, peripheral T cells recognize foreign antigens only in the context of self MHC antigens. This MHC restriction has been shown, at least in some cases, to be determined by radio resistant elements within the thymus (Zinkernagel, 1978). Under some experimental protocols, however, developing T cells acquire instead a preference for bone marrow derived MHC antigens (Katz et al., 1979, Zinkernagel et al., 1980).

Keywords

Immunoelectron Microscopy Principal Cell Thymic Epithelial Cell Human Thymus Mouse Thymus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Robert V. Rouse
    • 1
  • Irving L. Weissman
    • 1
  1. 1.Laboratory of Experimental Oncology, Department of PathologyStanford University Medical CenterStanfordUSA

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