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Morphological Assessment of Immunologically Relevant Cells in the Thymus

  • G. E. Dappen
  • D. A. Crouse
  • R. W. Anderson
  • R. K. Jordan
  • J. H. Robinson
  • J. G. Sharp
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)

Abstract

The thymus is the preferred site of amplification of the T cell compartment (1). This process is selective in that cytotoxic T cells, for example, recognize antigen preferentially in the context of the histocompatibility antigens expressed by thymus in which they differentiated and they require I-region compatible cooperating lymphohematopoietic cells for full expression of function (2). It appears that the preference for the non-I-region histocompatibility phenotype impressed by the thymus is a consequence of an interaction with radioresistant fixed cells of the thymus (2), probably epithelium, whereas the cooperating I-region requirement is imposed by immigrant thymic antigen-presenting cells (APC) (3).

Keywords

Erythroid Cell Morphological Assessment Fetal Thymus Birbeck Granule Mouse Thymus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • G. E. Dappen
    • 1
  • D. A. Crouse
    • 1
  • R. W. Anderson
    • 2
  • R. K. Jordan
    • 3
  • J. H. Robinson
    • 3
  • J. G. Sharp
    • 2
  1. 1.Department of BiologyNebraska Wesleyan University LincolnUSA
  2. 2.Department of AnatomyUniversity of Nebraska Medical CenterOmahaUSA
  3. 3.Department of AnatomyUniversity of Newcastle-upon-Tyne, EnglandUK

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