Morphological Assessment of Immunologically Relevant Cells in the Thymus

  • G. E. Dappen
  • D. A. Crouse
  • R. W. Anderson
  • R. K. Jordan
  • J. H. Robinson
  • J. G. Sharp
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


The thymus is the preferred site of amplification of the T cell compartment (1). This process is selective in that cytotoxic T cells, for example, recognize antigen preferentially in the context of the histocompatibility antigens expressed by thymus in which they differentiated and they require I-region compatible cooperating lymphohematopoietic cells for full expression of function (2). It appears that the preference for the non-I-region histocompatibility phenotype impressed by the thymus is a consequence of an interaction with radioresistant fixed cells of the thymus (2), probably epithelium, whereas the cooperating I-region requirement is imposed by immigrant thymic antigen-presenting cells (APC) (3).


Erythroid Cell Morphological Assessment Fetal Thymus Birbeck Granule Mouse Thymus 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • G. E. Dappen
    • 1
  • D. A. Crouse
    • 1
  • R. W. Anderson
    • 2
  • R. K. Jordan
    • 3
  • J. H. Robinson
    • 3
  • J. G. Sharp
    • 2
  1. 1.Department of BiologyNebraska Wesleyan University LincolnUSA
  2. 2.Department of AnatomyUniversity of Nebraska Medical CenterOmahaUSA
  3. 3.Department of AnatomyUniversity of Newcastle-upon-Tyne, EnglandUK

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