Monoclonal Antibodies Against Rat T Cells
In view of our interest in the role of various subpopulations of T lymphocytes in the process of immunological tolerance induction or rejection after allogeneic renal transplantation in an experimental rat model, we have started to produce monoclonal antibodies against cell surface determinants of cell types at various stages along the T cell lineage. Such cell types may represent an early phase in T cell differentiation, for example thymocytes, or more mature and functionally differentiated stages, such as T helper (1) or T suppressor cells (2). The present paper describes a primary analysis of three monoclonal antibodies, derived after fusion of the spleens of BALB/c mice immunized with rat thymocytes, with the mouse fusion line FO.
KeywordsSprague Dawley Fusion Line Lymphoid System Lymph Node Preparation Cell Surface Determinant
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