Monoclonal Antibodies Against Rat T Cells

  • J. Rozing
  • L. M. B. Vaessen
  • C. B. Carpenter
  • P. Joling
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


In view of our interest in the role of various subpopulations of T lymphocytes in the process of immunological tolerance induction or rejection after allogeneic renal transplantation in an experimental rat model, we have started to produce monoclonal antibodies against cell surface determinants of cell types at various stages along the T cell lineage. Such cell types may represent an early phase in T cell differentiation, for example thymocytes, or more mature and functionally differentiated stages, such as T helper (1) or T suppressor cells (2). The present paper describes a primary analysis of three monoclonal antibodies, derived after fusion of the spleens of BALB/c mice immunized with rat thymocytes, with the mouse fusion line FO.


Sprague Dawley Fusion Line Lymphoid System Lymph Node Preparation Cell Surface Determinant 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • J. Rozing
    • 1
  • L. M. B. Vaessen
    • 1
  • C. B. Carpenter
    • 2
  • P. Joling
    • 1
  1. 1.Dept. of Internal Medicine I, Renal DivisionErasmus UniversityRotterdamThe Netherlands
  2. 2.Dept. of Medicine, Renal DivisionHarvard UniversityBostonUSA

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