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Study of Beta Adrenoceptors on Subpopulations of Thymocytes Separated on Ficoll-Hypaque Density Gradients

  • Upendra Singh
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)

Abstract

In our earlier study we had identified beta adrenoceptors on fetal and newborn thymocytes (1). In view of the fact that thymocyte population in the adult is heterogeneous in terms of stages of maturation and functional competence, this research was undertaken to study the concentration of beta adrenoceptors on the sub-populations of thymocytes separated on discontinuous ficoll-hypaque density gradient (2) in order to examine any correlation between the concentration of these receptors and the immunological competence of various thymocyte subpopulations. In addition, comparison with splenic T lymphocytes, which are more immunoreactive than thymocytes and also differ in terms of adenylcyclase stimulation and levels of cAMP (3,4) have also been made.

Keywords

Adenyl Cyclase Lymphoid Cell Functional Competence Thymic Hormone Nylon Wool 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    U. Singh, D.S. Millson, P.A. Smith, and J.J.T. Owen. Eur. J. Immunol 9:31 (1979).PubMedCrossRefGoogle Scholar
  2. 2.
    U. Singh and J.J.T. Owen. Develop. Comp. Immunol. 3:543 (1979).CrossRefGoogle Scholar
  3. 3.
    D.E. Mosier, in: “Development of Host Defenses”, Raven Press, New York, p. 115 (1977).Google Scholar
  4. 4.
    M. Bach. S. Clin. Invest. 55:1094 (1975).Google Scholar
  5. 5.
    A. Boyum. Scand. J. Clin. Invest. 21: Wuppl. 97:77 (1968).Google Scholar
  6. 6.
    M.H. Julius, E. Simpson, and L.A. Herzenberg. Eur. J. Immunol. 3:645 (1973).PubMedCrossRefGoogle Scholar
  7. 7.
    N. Trainin, M. Small, and A.J. Kook, in: “B and T Cells in Immune Recognition”, John Wiley and Sons, London, p. 83 (1977).Google Scholar
  8. 8.
    M.H. Marman. Proc. Natl. Acad. Sci. 68:885 (1971).CrossRefGoogle Scholar
  9. 9.
    R.E. Callard, B.F. Groth, A. Basten, and I.F.C. McKenzie. J. Immunol. 124:52 (1980).PubMedGoogle Scholar
  10. 10.
    D.B. Garioch, R.A. Good, and R.A. Gatti. Lancet 1:618 (1980).Google Scholar
  11. 11.
    D.D. Schocken and G.S. Roth. Nature 267:856 (1977).PubMedCrossRefGoogle Scholar
  12. 12.
    J.R. sheppard, R. Gormens, and C.F. Moldow. Nature 269: 693 (1977).PubMedCrossRefGoogle Scholar
  13. 13.
    B. Weiss and R.A. Winchurch. Cancer Res. 28:1274 (1968).Google Scholar
  14. 14.
    R.H. DeKruyff, T.Y. Kim, G.W. Sisrind, and M.E. Weksler. J. Immunol. 125:142 (1980).Google Scholar
  15. 15.
    A. Yu, H. Watts, N. Jaffe, and R. Parkman. N. Eng. J. Med. 297:121 (1977).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Upendra Singh
    • 1
  1. 1.Department of AnatomyUniversity of Utah College of MedicineSalt Lake CityUSA

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