Structural and Functional Alterations of the Aging Human Thymus

  • H. K. Muller-Hermelink
  • G. Steinmann
  • H. Stein
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


If aging is regarded as a progressive loss of organ functions, the thymus may be considered as the first organ of the body involved in this process. Thymic involution starts when all other organs and tissues show increasing or peak values of functional and structural parameters. Since the involution of the thymus is suspected to be the structural basis of decreasing T-lymphocyte dependent immune functions with age, we were interested in giving a more detailed description of this process.


Lymphoid Cell Germinal Center Perivascular Space Thymic Tissue Thymic Involution 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • H. K. Muller-Hermelink
    • 1
  • G. Steinmann
    • 1
  • H. Stein
    • 1
  1. 1.Institute of PathologyChristian Albrecht UniversityKielGermany

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