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Accumulation of Mature T and B Cells and Abnormalities of Lymphocyte Traffic in the Thymus of Aged NZB × SJL F1 Female Mice

  • Francis Dumont
  • Robert C. Habbersett
  • Roger Barrois
  • Hubert Gerard
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)

Abstract

NZB × SJL F1 female (NSF) mice develop a dramatic hypertrophy of the thymus during aging, which provides a unique model of sex-dependent thymic pathology (1). The present report summarizes a series of studies intended at examining the significance of this phenomenon. In order to determine the cellular events underlying the thymic hypertrophy, we combined histological observations by light and electron microscopy with the phenotypic characterization of dissociated thymic cells using flow cytofluorometry (FCF) (2). Furthermore, we undertook homing experiments with radioactively labeled cells as an attempt to investigate the possibility that abnormalities of lymphocyte ecotaxis (3) might be associated with the aberrant behavior of the NSF thymus.

Keywords

Lymph Node Cell Peripheral Lymphocyte Thymic Cell Lymph Node Homing Homing Experiment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Francis Dumont
    • 1
    • 2
  • Robert C. Habbersett
    • 1
    • 2
  • Roger Barrois
    • 1
    • 2
  • Hubert Gerard
    • 1
    • 2
  1. 1.Dept. of ImmunologyMerck Sharp & Dohme Research LaboratoriesRahwayUSA
  2. 2.Unit of Experimental Cancerology, INSERM U95 and Dept. of HistologyFaculty of MedicineVandoeuvre-les-NancyFrance

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