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The Development of B Lymphocytes and Their Reactivity in Pig Fetuses

  • L. Jaroskova
  • F. Kovaru
  • H. Tlaskalova
  • I. Trebichavsky
  • L. Fornusek
  • M. Holub
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)

Abstract

The development of lymphatic tissues and immune reactivity under the limited antigenic contact in ontogeny of pigs has been reviewed by Sterzl and Kovaru (1). In the pig, as in other animal species, there are two distinct pathways of lymphoid cell differentiation leading to generation of B and T lymphocytes (2,3). First, lymphocytes which express markers of T-cell lineage (receptors for SRBC and binding sites for anti-pig T serum) appear in thymus and peripheral blood on day 38, in spleen on day 58 and react to T-cell mitogens (2,4). Surface IgM (sIgM) is a marker of B-cell lineage (5) and LPS-induced differentiation of lymphoid cells into blast-like cells in vitro starts after sIgM+ cells appear [liver — day 44, spleen — day 51 of gestation (6)].

Keywords

Complement Receptor Fetal Spleen Precolostral Piglet Plasma Cell Formation Newborn Precolostral Piglet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • L. Jaroskova
    • 1
  • F. Kovaru
    • 1
  • H. Tlaskalova
    • 1
  • I. Trebichavsky
    • 1
  • L. Fornusek
    • 1
  • M. Holub
    • 1
  1. 1.Institute of MicrobiologyCzech. Acad. Sci. and IKEMPragueCzechoslovakia

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