“Thymic Nurse Cells” Contain the First Virus Producing Cells after Inoculation of the Radiation Leukemia Virus in C57BL/Ka Mice
In mice, the development of thymic lymphomas either spontaneously, or after a treatment by irradiation chemicals or retroviruses, raises the question of the interactions between putative oncogenic factors and the normal pathway of T cell differentiation. Lymphomas induced by inoculation of the Radiation Leukemia Virus (RadLV)+ are good experimental models for studying such interactions. The injection of this virus into C57BL/Ka mice results in specific modifications, i.e. overt virus replication and eventual lymphoma development, which are selectively located within the thymus (review: Kaplan, 1977).
KeywordsLymphoid Cell Blast Cell Normal Thymus Thymic Lymphoma Virus Produce Cell
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