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“Thymic Nurse Cells” Contain the First Virus Producing Cells after Inoculation of the Radiation Leukemia Virus in C57BL/Ka Mice

  • Jacques Boniver
  • Marie-Paule Houben-Defresne
  • Andree Varlet
  • Gerard Goffinet
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)

Abstract

In mice, the development of thymic lymphomas either spontaneously, or after a treatment by irradiation chemicals or retroviruses, raises the question of the interactions between putative oncogenic factors and the normal pathway of T cell differentiation. Lymphomas induced by inoculation of the Radiation Leukemia Virus (RadLV)+ are good experimental models for studying such interactions. The injection of this virus into C57BL/Ka mice results in specific modifications, i.e. overt virus replication and eventual lymphoma development, which are selectively located within the thymus (review: Kaplan, 1977).

Keywords

Lymphoid Cell Blast Cell Normal Thymus Thymic Lymphoma Virus Produce Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Jacques Boniver
    • 1
  • Marie-Paule Houben-Defresne
    • 1
  • Andree Varlet
    • 1
  • Gerard Goffinet
    • 1
  1. 1.Laboratory of Pathological Anatomy, Institute of Pathology B.23University of Liege Sart TilmanLiegeBelgium

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