Sequential Development of Thy-1+ Subpopulations in Regenerating Thymus after Bone Marrow Transplantation

  • W. J. A. Boersma
  • J. J. Haaijman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


Mouse bone marrow contains multipotent stem cells which have been shown to function also as progenitor cells of the T cell lineage (1). The first cells that can be recognized as T cells during ontogeny and in newborns are found in the thymus and have Thy-1 surface markers (2,3). The density of Thy 1 on adult thymocytes is heterogenous. In general a low Thy 1+ and a high Thy 1+ subpopulation can be distinguished, which have been equated with medullary and cortical thymocytes, respectively. Shortman and Jackson (4) proposed a T cell differentiation model in which the two types of thymocytes belong to different subpopulations at least in adult mice. These subpopulations develop simultaneously and independently and each contain a proportion of cycling cells. In adult mice no evidence for a precursor product relationship between the two subpopulations has been established. In addition to this model that suggested a dualistic development, Mathieson et al. (5,6) presented evidence for a sequential and separated development of Lyt-1+ and Lyt-1,2,3+ thymocytes in fetal thymus.


Bone Marrow Transplantation Bone Marrow Cell Donor Cell Hank Balance Salt Solution Mouse Bone Marrow 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • W. J. A. Boersma
    • 1
  • J. J. Haaijman
    • 1
  1. 1.Institute for Experimental Gerontology TNORijswijkThe Netherlands

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