Role of Thymic Medullary Lymphocytes in the Intra-Thymic Maturation Process

  • Martine Papiernik
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


The circulation of T lymphocyte precursors through the thymus seems to be a necessary step for the maturation of T cells (1). However, the intimate mode of action of the thymic micro-environment is far from being clear. It has been well established that contact with thymic epithelium in vitro (2–3) or with thymic factors (4) leads to the appearance of T cell markers on prethymic precursors. Only very poor or no functional maturation could be obtained with “null” pre T cells from B mice or bone marrow (5,6,7) [in nude mice, functional maturation in vitro has been show to be by those cells bearing T cell markers (8)].


Bone Marrow Cell Spleen Cell Mixed Lymphocyte Reaction Functional Maturation Responder Cell 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Martine Papiernik
    • 1
  1. 1.INSERM U 25Hopital NeckerParis Cedex 15France

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