Detection of MHC, Thy-1, Lyt-1 And Lyt-2 Antigens in the Developing Mouse Thymus

  • W. van Ewijk
  • E. J. Jenkinson
  • P. L. van Soest
  • J. J. T. Owen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


The regulatory role of the thymus in the differentiation process of T lymphocytes has been well accepted (1,2). Functional distinct subclasses of T lymphocytes differentiate within the thymic compartment. These cells can be identified by virtue of the expression of Lyt antigens. Thus, T helper and T amplifier cells carry the Lyt-1+, 2-, 3+ phenotype (Lyt-1+ cells), whereas suppressor and cytotoxic T cells carry the Lyt-1-, 2+, 3+ phenotype (Lyt-2,3+ cells). Cantor and Boyse (3) have provided evidence that these cells originate from a precursor cell expressing the Lyt-1+, 2+, 3+ phenotype (Lyt-123+ cells).


Freeze Section Mouse Thymus Sequential Appearance Thymic Lobe Serial Freeze Section 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • W. van Ewijk
    • 1
  • E. J. Jenkinson
    • 2
  • P. L. van Soest
    • 1
  • J. J. T. Owen
    • 2
  1. 1.Department of Cell Biology and GeneticsErasmus UniversityRotterdamThe Netherlands
  2. 2.Department of AnatomyUniversity of BirminghamBirminghamEngland

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