Morphological Aspects of the Local Immune Response to Influenza in Rats

  • Zlatko R. Angelov
  • Ludmilla A. Angelova
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


Influenza viruses attack the ciliary epithelial cells of the respiratory tract, where they reproduce causing a sequence of clinically manifested symptoms with prevalency of general intoxication. The absence of viraemia and the restricted epitheliotropism of influenza makes this virus a very convenient model for studying the different aspects of the mucosal immunity in respiratory tract. The local anti-influenza defense at this site involves the respiratory epithelial cells and other nonimmunological factors as well as the components of the local immune apparatus, namely, mucosal lymphoid elements and regional lymph nodes (LN).


Germinal Center Hilar Lymph Node Popliteal Lymph Node Local Immune Response Primary Immune Response 


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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Zlatko R. Angelov
    • 1
  • Ludmilla A. Angelova
    • 1
  1. 1.Department of Anatomy and Histology and Department of Microbiology and VirologyInstitute of MedicineVarnaBulgaria

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